Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT

Benjamin H. Brinkmann; Richard A. Robb; Terence J. O’Brien; Michael K. O’Connor; Brian P. Mullan

doi:10.1007/bfb0056298

Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT

Benjamin H. Brinkmann, Richard A. Robb, Terence J. O’Brien, Michael K. O’Connor, Brian P. Mullan

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

5 Scopus citations

Abstract

Peri-ictal SPECT is a potentially powerful tool to study changes in regional cerebral blood flow during a partial seizure and to localize the seizure focus for pre-surgical evaluation. Recently we have developed and validated a method for co-registering and normalizing 3D interictal SPECT images to 3D ictal SPECT images and deriving a difference image co-registered to the patient's 3D MRI. This method has been shown to significantly improve clinical outcomes in surgery patients. In order to improve the method's sensitivity and specificity a number of enhancements have been added to the basic technique, including using voxel-based registration to better alignictal and interictal images, dual isotope (Tc-99m and 1-123) SPECT for effective tissue discrimination, and a custom software interface written to facilitate the entire process. We report results that show significant improvement over the original method, and we discuss future work which should continue to improve the method as a clinical tool.

Original language	English (US)
Title of host publication	Medical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings
Editors	William M. Wells, Alan Colchester, Scott Delp
Publisher	Springer Verlag
Pages	1087-1098
Number of pages	12
ISBN (Print)	3540651365, 9783540651369
DOIs	https://doi.org/10.1007/bfb0056298
State	Published - 1998
Event	1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998 - Cambridge, United States Duration: Oct 11 1998 → Oct 13 1998

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	1496
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998
Country/Territory	United States
City	Cambridge
Period	10/11/98 → 10/13/98

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

Access to Document

10.1007/bfb0056298

Cite this

Brinkmann, B. H., Robb, R. A., O’Brien, T. J., O’Connor, M. K., & Mullan, B. P. (1998). Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT. In W. M. Wells, A. Colchester, & S. Delp (Eds.), Medical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings (pp. 1087-1098). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1496). Springer Verlag. https://doi.org/10.1007/bfb0056298

Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT. / Brinkmann, Benjamin H.; Robb, Richard A.; O’Brien, Terence J. et al.
Medical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings. ed. / William M. Wells; Alan Colchester; Scott Delp. Springer Verlag, 1998. p. 1087-1098 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 1496).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Brinkmann, BH, Robb, RA, O’Brien, TJ, O’Connor, MK & Mullan, BP 1998, Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT. in WM Wells, A Colchester & S Delp (eds), Medical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 1496, Springer Verlag, pp. 1087-1098, 1st International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 1998, Cambridge, United States, 10/11/98. https://doi.org/10.1007/bfb0056298

Brinkmann BH, Robb RA, O’Brien TJ, O’Connor MK, Mullan BP. Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT. In Wells WM, Colchester A, Delp S, editors, Medical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings. Springer Verlag. 1998. p. 1087-1098. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). doi: 10.1007/bfb0056298

Brinkmann, Benjamin H. ; Robb, Richard A. ; O’Brien, Terence J. et al. / Multimodality imaging for epilepsy diagnosis and surgical focus localization : Three-dimensional image correlation and dual isotope SPECT. Medical Image Computing and Computer-Assisted Intervention ─ MICCAI 1998 - 1st International Conference, Proceedings. editor / William M. Wells ; Alan Colchester ; Scott Delp. Springer Verlag, 1998. pp. 1087-1098 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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Multimodality imaging for epilepsy diagnosis and surgical focus localization: Three-dimensional image correlation and dual isotope SPECT

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