Motor speech disorders associated with primary progressive aphasia

Joseph R. Duffy, Edythe A. Strand, Keith A. Josephs

Research output: Contribution to journalReview articlepeer-review

26 Scopus citations


Background: Primary progressive aphasia (PPA) and conditions that overlap with it can be accompanied by motor speech disorders. Recognition and understanding of motor speech disorders can contribute to a fuller clinical understanding of PPA and its management as well as its localisation and underlying pathology.Aims: To review the types of motor speech disorders that may occur with PPA, its primary variants, and its overlap syndromes (progressive supranuclear palsy syndrome, corticobasal syndrome, motor neuron disease), as well as with primary progressive apraxia of speech.Main Contribution: The review should assist clinicians' and researchers' understanding of the relationship between motor speech disorders and PPA and its major variants. It also highlights the importance of recognising neurodegenerative apraxia of speech as a condition that can occur with little or no evidence of aphasia.Conclusion: Motor speech disorders can occur with PPA. Their recognition can contribute to clinical diagnosis and management of PPA and to understanding and predicting the localisation and pathology associated with PPA variants and conditions that can overlap with them.

Original languageEnglish (US)
Pages (from-to)1004-1017
Number of pages14
Issue number8-9
StatePublished - Sep 2014


  • Apraxia of speech
  • Dysarthrias
  • Motor speech disorders
  • Primary progressive aphasia
  • Primary progressive apraxia of speech

ASJC Scopus subject areas

  • Otorhinolaryngology
  • Language and Linguistics
  • Developmental and Educational Psychology
  • Linguistics and Language
  • Neurology
  • Clinical Neurology
  • LPN and LVN


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