Modulation of CD4 by antigenic activation

C. M. Weyand, J. Goronzy, C. G. Fathman

Research output: Contribution to journalArticlepeer-review

98 Scopus citations


Cell surface expression of CD4, an invariant membrane glycoprotein, is characteristic of the MHC class II-restricted T cell helper/inducer subset. Although the specificity and restriction patterns of T lymphocytes are determined by the T cell receptor for antigen, CD4 might represent an additional 'interaction' molecule that is required to strengthen the interaction between T cells, antigen, and antigen-presenting cells. In this manuscript, we have shown that the cell surface expression of CD4 is correlated with activation of T cells. Data presented in this paper have demonstrated, for the first time, that antigenic stimulation of human T cell clones caused a decrease in the expression of the CD4 marker (as well as to the CD3 marker) to about 50% of the constitutive level. As previously demonstrated, PMA caused modulation of CD4 and CD3, which suggested that phosphorylation by protein kinase C played a crucial role in the regulation of the expression of both markers. The parallel down-regulation of CD3 and CD4 after antigen stimulation suggested that both markers might be members of a multimolecular complex mediating T cell activation.

Original languageEnglish (US)
Pages (from-to)1351-1354
Number of pages4
JournalJournal of Immunology
Issue number5
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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