Microscopic colitis

Darrell S. Pardi

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Microscopic colitis is a relatively common cause of chronic diarrhea. The colonic mucosa appears normal or nearly normal at endoscopy, and the diagnosis is made when there is intraepithelial lymphocytosis and a mixed inflammatory infiltrate in the lamina propria in the appropriate clinical setting. The two subtypes of colitis, collagenous and lymphocytic colitis, are simi-lar clinically and histologically and are differentiated primarily by the presence or absence of a thickened subepithelial collagen band. The possibility of drug-induced microscopic colitis and/or concomitant celiac sprue must be considered when evaluating these patients. Although there have been few controlled treatment trials in microscopic colitis, a systematic approach to therapy often leads to satisfactory control of symptoms.

Original languageEnglish (US)
Pages (from-to)283-288
Number of pages6
JournalGastroenterology and Hepatology
Issue number4
StatePublished - Apr 2009


  • Budesonide
  • Collagenous colitis
  • Lymphocytic colitis
  • Microscopic colitis

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


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