Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review

S. Raimondi; V. Paracchini; H. Autrup; J. M. Barros-Dios; S. Benhamou; P. Boffetta; M. L. Cote; I. A. Dialyna; V. Dolzan; R. Filiberti; S. Garte; A. Hirvonen; K. Husgafvel-Pursiainen; E. N. Imyanitov; I. Kalina; D. Kang; C. Kiyohara; T. Kohno; P. Kremers; Q. Lan; S. London; A. C. Povey; A. Rannug; E. Reszka; A. Risch; M. Romkes; J. Schneider; A. Seow; P. G. Shields; R. C. Sobti; M. Sørensen; M. Spinola; M. R. Spitz; R. C. Strange; I. Stücker; H. Sugimura; J. To-Figueras; S. Tokudome; P. Yang; J. M. Yuan; M. Warholm; E. Taioli

doi:10.1093/aje/kwj321

Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review

S. Raimondi, V. Paracchini, H. Autrup, J. M. Barros-Dios, S. Benhamou, P. Boffetta, M. L. Cote, I. A. Dialyna, V. Dolzan, R. Filiberti, S. Garte, A. Hirvonen, K. Husgafvel-Pursiainen, E. N. Imyanitov, I. Kalina, D. Kang, C. Kiyohara, T. Kohno, P. Kremers, Q. LanS. London, A. C. Povey, A. Rannug, E. Reszka, A. Risch, M. Romkes, J. Schneider, A. Seow, P. G. Shields, R. C. Sobti, M. Sørensen, M. Spinola, M. R. Spitz, R. C. Strange, I. Stücker, H. Sugimura, J. To-Figueras, S. Tokudome, P. Yang, J. M. Yuan, M. Warholm, E. Taioli

Quantitative Health Sciences

Research output: Contribution to journal › Review article › peer-review

116 Scopus citations

Abstract

Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

Original language	English (US)
Pages (from-to)	1027-1042
Number of pages	16
Journal	American journal of epidemiology
Volume	164
Issue number	11
DOIs	https://doi.org/10.1093/aje/kwj321
State	Published - Dec 2006

Keywords

Disease susceptibility
Epidemiology
GSTT1
Genes
Genetic predisposition to disease
Lung neoplasms
Meta-analysis

ASJC Scopus subject areas

Epidemiology

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10.1093/aje/kwj321

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Raimondi, S., Paracchini, V., Autrup, H., Barros-Dios, J. M., Benhamou, S., Boffetta, P., Cote, M. L., Dialyna, I. A., Dolzan, V., Filiberti, R., Garte, S., Hirvonen, A., Husgafvel-Pursiainen, K., Imyanitov, E. N., Kalina, I., Kang, D., Kiyohara, C., Kohno, T., Kremers, P., ... Taioli, E. (2006). Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review. American journal of epidemiology, 164(11), 1027-1042. https://doi.org/10.1093/aje/kwj321

Raimondi, S, Paracchini, V, Autrup, H, Barros-Dios, JM, Benhamou, S, Boffetta, P, Cote, ML, Dialyna, IA, Dolzan, V, Filiberti, R, Garte, S, Hirvonen, A, Husgafvel-Pursiainen, K, Imyanitov, EN, Kalina, I, Kang, D, Kiyohara, C, Kohno, T, Kremers, P, Lan, Q, London, S, Povey, AC, Rannug, A, Reszka, E, Risch, A, Romkes, M, Schneider, J, Seow, A, Shields, PG, Sobti, RC, Sørensen, M, Spinola, M, Spitz, MR, Strange, RC, Stücker, I, Sugimura, H, To-Figueras, J, Tokudome, S, Yang, P, Yuan, JM, Warholm, M & Taioli, E 2006, 'Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review', American journal of epidemiology, vol. 164, no. 11, pp. 1027-1042. https://doi.org/10.1093/aje/kwj321

@article{fc2f94fc30cd4c1b849b130e85c3624b,

title = "Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review",

abstract = "Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.",

keywords = "Disease susceptibility, Epidemiology, GSTT1, Genes, Genetic predisposition to disease, Lung neoplasms, Meta-analysis",

author = "S. Raimondi and V. Paracchini and H. Autrup and Barros-Dios, {J. M.} and S. Benhamou and P. Boffetta and Cote, {M. L.} and Dialyna, {I. A.} and V. Dolzan and R. Filiberti and S. Garte and A. Hirvonen and K. Husgafvel-Pursiainen and Imyanitov, {E. N.} and I. Kalina and D. Kang and C. Kiyohara and T. Kohno and P. Kremers and Q. Lan and S. London and Povey, {A. C.} and A. Rannug and E. Reszka and A. Risch and M. Romkes and J. Schneider and A. Seow and Shields, {P. G.} and Sobti, {R. C.} and M. S{\o}rensen and M. Spinola and Spitz, {M. R.} and Strange, {R. C.} and I. St{\"u}cker and H. Sugimura and J. To-Figueras and S. Tokudome and P. Yang and Yuan, {J. M.} and M. Warholm and E. Taioli",

year = "2006",

month = dec,

doi = "10.1093/aje/kwj321",

language = "English (US)",

volume = "164",

pages = "1027--1042",

journal = "American journal of epidemiology",

issn = "0002-9262",

publisher = "Oxford University Press",

number = "11",

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TY - JOUR

T1 - Meta- and pooled analysis of GSTT1 and lung cancer

T2 - A HuGE-GSEC review

AU - Raimondi, S.

AU - Paracchini, V.

AU - Autrup, H.

AU - Barros-Dios, J. M.

AU - Benhamou, S.

AU - Boffetta, P.

AU - Cote, M. L.

AU - Dialyna, I. A.

AU - Dolzan, V.

AU - Filiberti, R.

AU - Garte, S.

AU - Hirvonen, A.

AU - Husgafvel-Pursiainen, K.

AU - Imyanitov, E. N.

AU - Kalina, I.

AU - Kang, D.

AU - Kiyohara, C.

AU - Kohno, T.

AU - Kremers, P.

AU - Lan, Q.

AU - London, S.

AU - Povey, A. C.

AU - Rannug, A.

AU - Reszka, E.

AU - Risch, A.

AU - Romkes, M.

AU - Schneider, J.

AU - Seow, A.

AU - Shields, P. G.

AU - Sobti, R. C.

AU - Sørensen, M.

AU - Spinola, M.

AU - Spitz, M. R.

AU - Strange, R. C.

AU - Stücker, I.

AU - Sugimura, H.

AU - To-Figueras, J.

AU - Tokudome, S.

AU - Yang, P.

AU - Yuan, J. M.

AU - Warholm, M.

AU - Taioli, E.

PY - 2006/12

Y1 - 2006/12

N2 - Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

AB - Lung cancer is the most common malignancy in the Western world, and the main risk factor is tobacco smoking. Polymorphisms in metabolic genes may modulate the risk associated with environmental factors. The glutathione S-transferase theta 1 gene (GSTT1) is a particularly attractive candidate for lung cancer susceptibility because of its involvement in the metabolism of polycyclic aromatic hydrocarbons found in tobacco smoke and of other chemicals, pesticides, and industrial solvents. The frequency of the GSTT1 null genotype is lower among Caucasians (10-20%) than among Asians (50-60%). The authors present a meta- and a pooled analysis of case-control, genotype-based studies that examined the association between GSTT1 and lung cancer (34 studies, 7,629 cases and 10,087 controls for the meta-analysis; 34 studies, 7,044 cases and 10,000 controls for the pooled analysis). No association was observed between GSTT1 deletion and lung cancer for Caucasians (odds ratio (OR) = 0.99, 95% confidence interval (CI): 0.87, 1.12); for Asians, a positive association was found (OR = 1.28, 95% CI: 1.10, 1.49). In the pooled analysis, the odds ratios were not significant for either Asians (OR = 0.97, 95% CI: 0.83, 1.13) or Caucasians (OR = 1.09, 95% CI: 0.99, 1.21). No significant interaction was observed between GSTT1 and smoking on lung cancer, whereas GSTT1 appeared to modulate occupational-related lung cancer.

KW - Disease susceptibility

KW - Epidemiology

KW - GSTT1

KW - Genes

KW - Genetic predisposition to disease

KW - Lung neoplasms

KW - Meta-analysis

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UR - http://www.scopus.com/inward/citedby.url?scp=33845215407&partnerID=8YFLogxK

U2 - 10.1093/aje/kwj321

DO - 10.1093/aje/kwj321

M3 - Review article

C2 - 17000715

AN - SCOPUS:33845215407

SN - 0002-9262

VL - 164

SP - 1027

EP - 1042

JO - American journal of epidemiology

JF - American journal of epidemiology

IS - 11

ER -

Meta- and pooled analysis of GSTT1 and lung cancer: A HuGE-GSEC review

Abstract

Keywords

ASJC Scopus subject areas

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