Mechanisms of Action of Antiepileptic Drugs

Jeffrey W. Britton, Tarek M. Zakaria, Eduardo Benarroch

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations
Original languageEnglish (US)
Title of host publicationAdult Epilepsy
PublisherJohn Wiley and Sons
Number of pages17
ISBN (Print)9780470741221
StatePublished - Mar 18 2011


  • Carbonic anhydrase inhibition - increasing concentration of intracellular hydrogen ions
  • Epilepsy treatment, and selection - without firm understanding of pathophysiology of ictogenesis, or pharmaceutical mechanism of action
  • Excitatory mechanisms targeted by AEDs
  • Inhibitory mechanisms, targeted by AEDs - GABAA receptors/channels
  • L-type calcium channels - and L-type calcium channels (Cav 1.2) in neuronal dendrites and cell bodies
  • Main mechanisms of action of AEDs
  • Mechanisms of action, early generation AEDs - understood after clinical use is established
  • Newer AEDs, acting through mechanisms - reducing neuronal excitability, burst firing or abnormal synchronization
  • Principles of medical management - mechanisms of action of antiepileptic drugs
  • Valid antiepileptic drug (AED) options - in treatment of epilepsy and seizures

ASJC Scopus subject areas

  • Neuroscience(all)

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