Mechanical factors and bone health: Effects of weightlessness and neurologic injury

Shreyasee Amin

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Bone is a dynamic tissue with homeostasis governed by many factors. Among them, mechanical stimuli appear to be particularly critical for bone structure and strength. With removal of mechanical stimuli, a profound bone loss occurs, as best observed in the extreme examples following exposure to space flight or neurologic impairment. This review provides an overview of the changes in bone density and structure that occur during and after space flight as well as following neurologic injury from stroke and spinal cord injury. It also discusses the potential mechanisms through which mechanical stimuli are postulated to act on bone tissue.

Original languageEnglish (US)
Pages (from-to)170-176
Number of pages7
JournalCurrent rheumatology reports
Issue number3
StatePublished - Jun 2010


  • Bone density
  • Mechanical stimuli
  • Space Flight
  • Spinal cord injury
  • Stroke
  • Weightlessness

ASJC Scopus subject areas

  • Rheumatology


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