Mechanical closure devices for atrial fibrillation

Matthew J. Price, David Holmes

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Atrial fibrillation (AF) is the most commonly sustained arrhythmia and is a major cause of stroke and systemic embolism. Chronic oral anticoagulation reduces this risk, but at the cost of increased bleeding. In addition, a substantial proportion of AF patients who are at moderate-to-high risk for stroke are undertreated due to real or perceived contraindications. The major source of thromboembolism in AF appears to be the left atrial appendage (LAA). Therefore, device closure of the LAA represents a mechanical approach to stroke prevention in AF patients. In this review, we describe the rationale for device closure of the LAA, summarize the current dataset for LAA closure devices, and set forth a framework to help guide patient selection for device therapy.

Original languageEnglish (US)
Pages (from-to)225-231
Number of pages7
JournalTrends in cardiovascular medicine
Issue number6
StatePublished - Aug 1 2014
Externally publishedYes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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