Measurement of spatial distribution of refractive index in tissues by ultrasonic computer assisted tomography

James F. Greenleaf; Steven A. Johnson; Arnold H. Lent

doi:10.1016/0301-5629(78)90075-3

Measurement of spatial distribution of refractive index in tissues by ultrasonic computer assisted tomography

James F. Greenleaf, Steven A. Johnson, Arnold H. Lent

Physiology & Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

60 Scopus citations

Abstract

Computerized tomography is used to calculate two independent images representing distributions of refractive index (n) and acoustic attenuation (α) within 1-3 mm thick cross-sections through excised organs, including canine hearts and human breasts. Values of n and α are calculated from profiles of propagation times and amplitudes, respectively, of digitized acoustic pulses obtained by rectilinear transmission scans of the tissue at multiple angles of view. Images of the local speed of ultrasound show high values in regions of muscle, breast parenchyma, medullary carcinoma and connective tissue and show low values in regions of fat. Images of acoustic attenuation show high values in regions of connective tissue and borders of scirrhus carcinoma and low values in regions of fat.

Original language	English (US)
Pages (from-to)	327-335,337-339
Journal	Ultrasound in Medicine and Biology
Volume	3
Issue number	4
DOIs	https://doi.org/10.1016/0301-5629(78)90075-3
State	Published - 1978

Keywords

Acoustic attenuation
Reconstruction
Refraction index
Tissues
Ultrasound
Velocity

ASJC Scopus subject areas

Biophysics
Radiological and Ultrasound Technology
Acoustics and Ultrasonics

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10.1016/0301-5629(78)90075-3

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@article{039592dddf5046ae9432448e85581be1,

title = "Measurement of spatial distribution of refractive index in tissues by ultrasonic computer assisted tomography",

abstract = "Computerized tomography is used to calculate two independent images representing distributions of refractive index (n) and acoustic attenuation (α) within 1-3 mm thick cross-sections through excised organs, including canine hearts and human breasts. Values of n and α are calculated from profiles of propagation times and amplitudes, respectively, of digitized acoustic pulses obtained by rectilinear transmission scans of the tissue at multiple angles of view. Images of the local speed of ultrasound show high values in regions of muscle, breast parenchyma, medullary carcinoma and connective tissue and show low values in regions of fat. Images of acoustic attenuation show high values in regions of connective tissue and borders of scirrhus carcinoma and low values in regions of fat.",

keywords = "Acoustic attenuation, Reconstruction, Refraction index, Tissues, Ultrasound, Velocity",

author = "Greenleaf, {James F.} and Johnson, {Steven A.} and Lent, {Arnold H.}",

note = "Funding Information: *This research was supported by Grants N01-HV-4-2904, HL04664, HL18968, and RR-7 and HL00060 from the National Institutes of Health, United States Public Health Service; AF 49620-76-C-001 from the United States Air Force; CB-64041 and CB-53860 from National Cancer Institute; and MCS75-22347 from the National Science Foundation.",

year = "1978",

doi = "10.1016/0301-5629(78)90075-3",

language = "English (US)",

volume = "3",

pages = "327--335,337--339",

journal = "Ultrasound in Medicine and Biology",

issn = "0301-5629",

publisher = "Elsevier USA",

number = "4",

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TY - JOUR

T1 - Measurement of spatial distribution of refractive index in tissues by ultrasonic computer assisted tomography

AU - Greenleaf, James F.

AU - Johnson, Steven A.

AU - Lent, Arnold H.

N1 - Funding Information: *This research was supported by Grants N01-HV-4-2904, HL04664, HL18968, and RR-7 and HL00060 from the National Institutes of Health, United States Public Health Service; AF 49620-76-C-001 from the United States Air Force; CB-64041 and CB-53860 from National Cancer Institute; and MCS75-22347 from the National Science Foundation.

PY - 1978

Y1 - 1978

N2 - Computerized tomography is used to calculate two independent images representing distributions of refractive index (n) and acoustic attenuation (α) within 1-3 mm thick cross-sections through excised organs, including canine hearts and human breasts. Values of n and α are calculated from profiles of propagation times and amplitudes, respectively, of digitized acoustic pulses obtained by rectilinear transmission scans of the tissue at multiple angles of view. Images of the local speed of ultrasound show high values in regions of muscle, breast parenchyma, medullary carcinoma and connective tissue and show low values in regions of fat. Images of acoustic attenuation show high values in regions of connective tissue and borders of scirrhus carcinoma and low values in regions of fat.

AB - Computerized tomography is used to calculate two independent images representing distributions of refractive index (n) and acoustic attenuation (α) within 1-3 mm thick cross-sections through excised organs, including canine hearts and human breasts. Values of n and α are calculated from profiles of propagation times and amplitudes, respectively, of digitized acoustic pulses obtained by rectilinear transmission scans of the tissue at multiple angles of view. Images of the local speed of ultrasound show high values in regions of muscle, breast parenchyma, medullary carcinoma and connective tissue and show low values in regions of fat. Images of acoustic attenuation show high values in regions of connective tissue and borders of scirrhus carcinoma and low values in regions of fat.

KW - Acoustic attenuation

KW - Reconstruction

KW - Refraction index

KW - Tissues

KW - Ultrasound

KW - Velocity

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U2 - 10.1016/0301-5629(78)90075-3

DO - 10.1016/0301-5629(78)90075-3

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AN - SCOPUS:0017813001

SN - 0301-5629

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SP - 327-335,337-339

JO - Ultrasound in Medicine and Biology

JF - Ultrasound in Medicine and Biology

IS - 4

ER -

Measurement of spatial distribution of refractive index in tissues by ultrasonic computer assisted tomography

Abstract

Keywords

ASJC Scopus subject areas

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