Mayo Clinic Clival Chordoma Case Series: Impact of Endoscopic Training on Clinical Care

Sukwoo Hong, Nadia Laack, Anita Mahajan, Erin K. O’Brien, Janalee K. Stokken, Jeffrey R. Janus, Garret Choby, Jamie J. Van Gompel

Research output: Contribution to journalArticlepeer-review


The management of clival chordoma in our group shifted around 2013 to mostly endoscopic, and proton beam was introduced for our multidisciplinary team. Consecutive patients who had surgical resection from 1987 to 2021 were reviewed. A total of 58 patients (39 patients after 2013) were analyzed. The mean tumor size was 3.7 cm, and the most common location was the upper clivus (43%). Compared to before 2013, after 2013, the endoscopic endonasal approach was more common (90%, p < 0.001), and more gross or near total resections (64%, p = 0.002) were attained. Ten cases (17%) were revision surgeries referred from elsewhere, and three cases (5%) underwent additional surgery elsewhere before adjuvant radiation. The postoperative cerebrospinal fluid leak occurred in 7%. Post-operative new cranial nerve deficits occurred in 32% before 2013, compared to 2.6% after 2013 (p = 0.004). For cases before 2013, 10 patients (53%) recurred during the median follow-up of 144 months (mean, 142 months), whereas for cases after 2013, seven patients (18%) recurred with a median follow-up of 35 months (mean, 42 months). 5-year progression-free survival was 58%, and 5-year overall survival was 87%. A specialized multidisciplinary team improved the resection rate compared to a historical cohort with an excellent morbidity profile.

Original languageEnglish (US)
Article number5104
Issue number20
StatePublished - Oct 2022


  • adjuvant radiation
  • chordoma
  • clivus
  • endoscopic
  • multidisciplinary
  • proton
  • skull base

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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