@article{f7435288e91342d49603cfc80504a47f,
title = "Mass cytometry identifies expansion of double positive and exhausted T cell subsets in the tumour microenvironment of patients with POEMS syndrome",
abstract = "We sought to dissect the tumour microenvironment in a small cohort (N = 10) of patients with POEMS at diagnosis and after therapy using mass cytometry. We included 10 MGUS patients as controls. We identified 29 immune cell subsets in the CD45+ and CD3+ compartments. Double positive T cells and PD-1 positive CD4 T cells were expanded and na{\"i}ve CD4 T cells were decreased in the bone marrow of patients with newly diagnosed/progressing POEMS. These findings provide evidence for possible antigenic-driven selection as a driver of disease pathogenesis in POEMS.",
keywords = "immunohaematology, immunophenotyping, myeloma, tumour immunology",
author = "Kourelis, {Taxiarchis V.} and Dragan Jevremovic and Erik Jessen and Surendra Dasari and Villasboas, {Jose C.} and Angela Dispenzieri and Shaji Kumar",
note = "Funding Information: This work was supported by a Career enhancement award/Mayo Clinic Myeloma SPORE P50 CA186781‐03 NIH grant and Division of Hematology {\textquoteleft}Small Grants Program{\textquoteright}. Funding Information: This work was supported by a Career enhancement award/Mayo Clinic Myeloma SPORE P50 CA186781-03 NIH grant and Division of Hematology {\textquoteleft}Small Grants Program{\textquoteright}. The authors would like to acknowledge Teresa Kimlinger (Division of Hematology) for providing administrative support and direct technical assistance and Dr. Kevin Brown (senior field application scientist, Fluidigm) for his assistance during panel design. We would also like to acknowledge the Predolin foundation for the provision of biobanked samples and the Mayo Clinic multiple myeloma SPORE for its support. Publisher Copyright: {\textcopyright} 2020 British Society for Haematology and John Wiley & Sons Ltd",
year = "2020",
month = jul,
day = "1",
doi = "10.1111/bjh.16522",
language = "English (US)",
volume = "190",
pages = "79--83",
journal = "British journal of haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "1",
}