TY - JOUR
T1 - Marital status is an independent prognostic factor for tracheal cancer patients
T2 - An analysis of the SEER database
AU - Li, Mu
AU - Dai, Chen Yang
AU - Wang, Yu Ning
AU - Chen, Tao
AU - Wang, Long
AU - Yang, Ping
AU - Xie, Dong
AU - Mao, Rui
AU - Chen, Chang
N1 - Funding Information:
The authors acknowledge the efforts of the Surveillance, Epidemiology, and End Results (SEER) Program tumor registries in providing high quality open resources for researchers. Mu Li, Chenyang Dai and Chang Chen designed the study and wrote the manuscript. Tao Chen, Rui Mao and Long Wang collected the relevant papers and data. Mu Li and Yuning Wang analyzed the data. Dong Xie and Ping Yang contributed in study design, statistical analysis and manuscript editing. All authors reviewed the manuscript. This study was supported by supported by the grants from the National Natural Science Foundation of China (No.81570014) and the projects from Science and Technology Commission of Shanghai Municipality (No.15JC1490900 and No.14411962600), Shanghai Pujiang Program (15PJD034), and Health and Family Planning Commission of Shanghai Municipality (No.2013ZYJB0003).
PY - 2016
Y1 - 2016
N2 - Background: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. Results: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64-0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54-0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53-0.93, p = 0.015). Methods: We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages. Conclusions: Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors.
AB - Background: Although marital status is an independent prognostic factor in many cancers, its prognostic impact on tracheal cancer has not yet been determined. The goal of this study was to examine the relationship between marital status and survival in patients with tracheal cancer. Results: Compared with unmarried patients (42.67%), married patients (57.33%) had better 5-year OS (25.64% vs. 35.89%, p = 0.009) and 5-year TCSS (44.58% vs. 58.75%, p = 0.004). Results of multivariate analysis indicated that marital status is an independent prognostic factor, with married patients showing better OS (hazard ratio [HR] = 0.78, 95% confidence interval [CI] 0.64-0.95, p = 0.015) and TCSS (HR = 0.70, 95% CI 0.54-0.91, p = 0.008). In addition, subgroup analysis suggested that marital status plays a more important role in the TCSS of patients with non-low-grade malignant tumors (HR = 0.71, 95% CI 0.53-0.93, p = 0.015). Methods: We extracted 600 cases from the Surveillance, Epidemiology, and End Results (SEER) database. Variables were compared by Pearson chi-squared test, t-test, log-rank test, and multivariate Cox regression analysis. Overall survival (OS) and tracheal cancer-specific survival (TCSS) were compared between subgroups with different pathologic features and tumor stages. Conclusions: Marital status is an independent prognostic factor for survival in patients with tracheal cancer. For that reason, additional social support may be needed for unmarried patients, especially those with non-low-grade malignant tumors.
KW - Marital status
KW - SEER
KW - Socio-economics
KW - Survival analysis
KW - Tracheal cancer
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U2 - 10.18632/oncotarget.12809
DO - 10.18632/oncotarget.12809
M3 - Article
C2 - 27780931
AN - SCOPUS:84998679039
SN - 1949-2553
VL - 7
SP - 77152
EP - 77162
JO - Oncotarget
JF - Oncotarget
IS - 47
ER -