@article{43c7cc4ff1d641bea93c46bb2025ec79,
title = "Mapping ventricular expansion onto cortical gray matter in older adults",
abstract = "Dynamic changes in the brain's lateral ventricles on magnetic resonance imaging are powerful biomarkers of disease progression in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Ventricular measures can represent accumulation of diffuse brain atrophy with very high effect sizes. Despite having no direct role in cognition, ventricular expansion co-occurs with volumetric loss in gray and white matter structures. To better understand relationships between ventricular and cortical changes over time, we related ventricular expansion to atrophy in cognitively relevant cortical gray matter surfaces, which are more challenging to segment. In ADNI participants, percent change in ventricular volumes at 1-year (N= 677) and 2-year (N= 536) intervals was significantly associated with baseline cortical thickness and volume in the full sample controlling for age, sex, and diagnosis, and in MCI separately. Ventricular expansion in MCI was associated with thinner gray matter in frontal, temporal, and parietal regions affected by AD. Ventricular expansion reflects cortical atrophy in early AD, offering a useful biomarker for clinical trials of interventions to slow AD progression.",
keywords = "Alzheimer's disease, Biomarkers, Brain imaging, Brain structure, Cortical, Gray matter, Longitudinal, Magnetic resonance imaging (MRI), Mild cognitive impairment, Surface area, Thickness, Volume",
author = "{for the Alzheimer's Disease Neuroimaging Initiative (ADNI)} and Madsen, {Sarah K.} and Gutman, {Boris A.} and Joshi, {Shantanu H.} and Toga, {Arthur W.} and Jack, {Clifford R.} and Weiner, {Michael W.} and Thompson, {Paul M.}",
note = "Funding Information: This research was also supported by a National Defense Science and Engineering Graduate (NDSEG) Fellowship (32 CFR 168a) to Sarah K. Madsen from the U.S. Department of Defense , and Air Force Office of Scientific Research . Algorithm development and image analysis for this study was funded, in part, by grants to Paul M. Thompson from the National Institute of Biomedical Imaging and Bioengineering ( R01 EB008281 , R01 EB008432 ) and by the National Institute on Aging , National Institute of Biomedical Imaging and Bioengineering , National Institute of Mental Health , the U.S. National Library of Medicine , and the National Center for Research Resources ( AG016570 , AG040060 , EB01651 , MH097268 , LM05639 , and RR019771 to Paul M. Thompson). Data collection and sharing for this project was funded by ADNI ( National Institutes of Health grant U01 AG024904 ). ADNI is funded by the National Institute on Aging , the National Institute of Biomedical Imaging and Bioengineering , and through contributions from the following: Abbott ; Alzheimer's Association ; Alzheimer Drug Discovery Foundation ; Amorfix Life Sciences Ltd ; AstraZeneca ; Bayer Healthcare ; BioClinica, Inc ; Biogen Idec Inc; Bristol-Myers Squibb Foundation ; Eisai ; Elan Pharmaceuticals Inc ; Eli Lilly and Company ; F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc ; GE Healthcare ; Innogenetics, N.V. ; IXICO Ltd ; Janssen Alzheimer Immunotherapy Research & Development, LLC ; Johnson & Johnson Pharmaceutical Research & Development LLC ; Medpace, Inc ; Merck & Co, Inc ; Meso Scale Diagnostics, LLC ; Novartis Pharmaceuticals Corporation ; Pfizer ; Servier; Synarc Inc ; and Takeda Pharmaceuticals North America . The Canadian Institutes of Health Research is providing funds to support ADNI clinical sites in Canada. Private sector contributions are facilitated by the Foundation for the National Institutes of Health. The grantee organization is the Northern California Institute for Research and Education , and the study is coordinated by the Alzheimer's Disease Cooperative Study at the University of California, San Diego. ADNI data are disseminated by the Laboratory for Neuro Imaging at the University of Southern California. This research was also supported by National Institutes of Health grants P30 AG010129 and K01 AG030514 from the National Institute of General Medical Sciences. Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
month = jan,
day = "1",
doi = "10.1016/j.neurobiolaging.2014.03.044",
language = "English (US)",
volume = "36",
pages = "S32--S41",
journal = "Neurobiology of aging",
issn = "0197-4580",
publisher = "Elsevier Inc.",
number = "S1",
}