Management Options for Irritable Bowel Syndrome

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Irritable bowel syndrome (IBS) is associated with diverse pathophysiologic mechanisms. These mechanisms include increased abnormal colonic motility or transit, intestinal or colorectal sensation, increased colonic bile acid concentration, and superficial colonic mucosal inflammation, as well as epithelial barrier dysfunction, neurohormonal up-regulation, and activation of secretory processes in the epithelial layer. Novel approaches to treatment include lifestyle modification, changes in diet, probiotics, and pharmacotherapy directed to the motility, sensation, and intraluminal milieu of patients with IBS. Despite recent advances, there is a need for development of new treatments to relieve pain in IBS without deleterious central or other adverse effects.

Original languageEnglish (US)
Pages (from-to)1858-1872
Number of pages15
JournalMayo Clinic proceedings
Issue number12
StatePublished - Dec 2018

ASJC Scopus subject areas

  • Medicine(all)


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