Magnetic resonance elastography of the brain

Scott A. Kruse, Gregory H. Rose, Kevin J. Glaser, Armando Manduca, Joel P. Felmlee, Clifford R. Jack, Richard L. Ehman

Research output: Contribution to journalArticlepeer-review

287 Scopus citations


The purpose of this study was to obtain normative data using magnetic resonance elastography (MRE) (a) to obtain estimates of the shear modulus of human cerebral tissue in vivo and (b) to assess a possible age dependence of the shear modulus of cerebral tissue in healthy adult volunteers. MR elastography studies were performed on tissue-simulating gelatin phantoms and 25 healthy adult volunteers. The data were analyzed using spatiotemporal filters and a local frequency estimating algorithm. Statistical analysis was performed using a paired t-test. The mean shear stiffness of cerebral white matter was 13.6 kPa (95% CI 12.3 to 14.8 kPa); while that of gray matter was lower at 5.22 kPa (95% CI 4.76 to 5.66 kPa). The difference was statistically significant (p < 0.0001).

Original languageEnglish (US)
Pages (from-to)231-237
Number of pages7
Issue number1
StatePublished - Jan 1 2008


  • Brain
  • Elasticity
  • Magnetic resonance elastography
  • Mechanical properties
  • Shear stiffness
  • Tissue characterization

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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