Lupus-related single nucleotide polymorphisms and risk of diffuse large B-cell lymphoma

Sasha Bernatsky, Héctor A.Velásquez García, John J. Spinelli, Patrick Gaffney, Karin E. Smedby, Rosalind Ramsey-Goldman, Sophia S. Wang, Hans Olov Adami, Demetrius Albanes, Emanuele Angelucci, Stephen M. Ansell, Yan WAsmann, Nikolaus Becker, Yolanda Benavente, Sonja I. Berndt, Kimberly A. Bertrand, Brenda M. Birmann, Heiner Boeing, Paolo Boffetta, Paige M. BracciPaul Brennan, Angela R. Brooks-Wilson, James R. Cerhan, Stephen J. Chanock, Jacqueline Clavel, Lucia Conde, Karen H. Cotenbader, David G. Cox, Wendy Cozen, Simon Crouch, Anneclaire J. De Roos, Silvia De Sanjose, Simonetta Di Lollo, W. Ryan Diver, Ahmet Dogan, Lenka Foretova, Hervé Ghesquières, Graham G. Giles, Bengt Glimelius, Thomas M. Habermann, Corinne Haioun, Patricia Hartge, Henrik Hjalgrim, Theodore R. Holford, Elizabeth A. Holly, Rebecca D. Jackson, Rudolph Kaaks, Eleanor Kane, Rachel S. Kelly, Robert J. Klein, Peter Kraft, Anne Kricker, Qing Lan, Charles Lawrence, Mark Liebow, Tracy Lightfoot, Brian K. Link, Marc Maynadie, James McKay, Mads Melbye, Thierry J. Molina, Alain Monnereau, Lindsay M. Morton, Alexandra Nieters, Kari E. North, Anne J. Novak, Kenneth Offit, Mark P. Purdue, Marco Rais, Jacques Riby, Eve Roman, Nathaniel Rothman, Gilles Salles, Gianluca Severi, Richard K. Severson, Christine F. Skibola, Susan L. Slager, Alex Smith, Martyn T. Smith, Melissa C. Southey, Anthony Staines, Lauren R. Teras, Carrie A. Thompson, Hervé Tilly, Lesley F. Tinker, Anne Tjonneland, Jenny Turner, Claire M. Vajdic, Roel C.H. Vermeulen, Joseph Vijai, Paolo Vineis, Jarmo Virtamo, Zhaoming Wang, Stephanie Weinstein, Thomas E. Witzig, Andrew Zelenetz, Anne Zeleniuch-Jacquotte, Yawei Zhang, Tongzhang Zheng, Mariagrazia Zucca, Ann E. Clarke

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Objective: Determinants of the increased risk of diffuse large B-cell lymphoma (DLBCL) in SLE are unclear. Using data from a recent lymphoma genomewide association study (GWAS), we assessed whether certain lupus-related single nucleotide polymorphisms (SNPs) were also associated with DLBCL. Methods: GWAS data on European Caucasians from the International Lymphoma Epidemiology Consortium (InterLymph) provided a total of 3857 DLBCL cases and 7666 general-population controls. Data were pooled in a random-effects meta-analysis. Results: Among the 28 SLE-related SNPs investigated, the two most convincingly associated with risk of DLBCL included the CD40 SLE risk allele rs4810485 on chromosome 20q13 (OR per risk allele=1.09, 95% CI 1.02 to 1.16, p=0.0134), and the HLA SLE risk allele rs1270942 on chromosome 6p21.33 (OR per risk allele=1.17, 95% CI 1.01 to 1.36, p=0.0362). Of additional possible interest were rs2205960 and rs12537284. The rs2205960 SNP, related to a cytokine of the tumour necrosis factor superfamily TNFSF4, was associated with an OR per risk allele of 1.07, 95% CI 1.00 to 1.16, p=0.0549. The OR for the rs12537284 (chromosome 7q32, IRF5 gene) risk allele was 1.08, 95% CI 0.99 to 1.18, p=0.0765. Conclusions: These data suggest several plausible genetic links between DLBCL and SLE.

Original languageEnglish (US)
Article numbere000187
JournalLupus Science and Medicine
Issue number1
StatePublished - Jan 2017

ASJC Scopus subject areas

  • Rheumatology
  • Immunology


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