Low frequency of Helicobacter DNA in benign and malignant liver tissues from Baltimore, United States

Perumal Vivekanandan, Michael Torbenson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Helicobacter DNA has been reported in hepatocellular carcinoma tissues in several studies from varying geographic locations, raising the possibility that Helicobacter infection may contribute to the pathogenesis of hepatocellular carcinoma. Other known risk factors for hepatocellular carcinoma show significant geographic variability, but whether the same holds for Helicobacter is unknown. We studied the prevalence of Helicobacter DNA in a US cohort of hepatocellular carcinoma, where the prevalence of Helicobacter infection is low in the general population. Liver tissues from 57 individuals were examined. Thirty-five individuals had paired tumor/nontumor samples, including 21 cases of hepatocellular carcinoma, for a total of 92 samples studied. Both Helicobacter genus and Helicobacter pylori species-specific polymerase chain reaction was performed. Helicobacter DNA was detected in 5 (9%) of 57 cases, all in nonneoplastic cirrhotic liver tissues from individuals with hepatitis C infection (n = 4) or alcohol liver disease (n = 1). Tissues from 22 hepatocellular carcinomas and 10 cholangiocarcinomas were all negative as were tissues from 8 benign primary hepatic tumors. In conclusion, Helicobacter DNA was detectable in 9% of liver tissues in this cohort but was not found in primary benign or malignant liver tumors. These findings indicate that Helicobacter infection is unlikely to be etiologically associated with hepatocellular carcinoma in this cohort. If Helicobacter infection does contribute to the development of hepatocellular carcinoma in general, then significant regional variability must exist.

Original languageEnglish (US)
Pages (from-to)213-216
Number of pages4
JournalHuman Pathology
Issue number2
StatePublished - Feb 2008


  • Cholangiocarcinoma
  • Helicobacter
  • Hepatocellular carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


Dive into the research topics of 'Low frequency of Helicobacter DNA in benign and malignant liver tissues from Baltimore, United States'. Together they form a unique fingerprint.

Cite this