TY - JOUR
T1 - Longevity leap
T2 - mind the healthspan gap
AU - Garmany, Armin
AU - Yamada, Satsuki
AU - Terzic, Andre
N1 - Funding Information:
A.T. acknowledges his tenure as the Michael S. and Mary Sue Shannon Family Director, Center for Regenerative Medicine, Marriott Family Director, Comprehensive Cardiac Regenerative Medicine, and Marriott Family Professor at Mayo Clinic. Authors are supported by the National Institutes of Health (R01 HL134664), Marriott Family Foundation, Van Cleve Cardiac Regenerative Medicine Program, Mayo Clinic Center for Regenerative Medicine, Gerstner Family Foundation, Mayo Clinic Center for Individualized Medicine, and Medical Scientist Training Program at Mayo Clinic.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Life expectancy has increased by three decades since the mid-twentieth century. Parallel healthspan expansion has however not followed, largely impeded by the pandemic of chronic diseases afflicting a growing older population. The lag in quality of life is a recognized challenge that calls for prioritization of disease-free longevity. Contemporary communal, clinical and research trends aspiring to extend the health horizon are here outlined in the context of an evolving epidemiology. A shared action integrating public and societal endeavors with emerging interventions that target age-related multimorbidity and frailty is needed. A multidimensional buildout of a curative perspective, boosted by modern anti-senescent and regenerative technology with augmented decision making, would require dedicated resources and cost-effective validation to responsibly bridge the healthspan-lifespan gap for a future of equitable global wellbeing.
AB - Life expectancy has increased by three decades since the mid-twentieth century. Parallel healthspan expansion has however not followed, largely impeded by the pandemic of chronic diseases afflicting a growing older population. The lag in quality of life is a recognized challenge that calls for prioritization of disease-free longevity. Contemporary communal, clinical and research trends aspiring to extend the health horizon are here outlined in the context of an evolving epidemiology. A shared action integrating public and societal endeavors with emerging interventions that target age-related multimorbidity and frailty is needed. A multidimensional buildout of a curative perspective, boosted by modern anti-senescent and regenerative technology with augmented decision making, would require dedicated resources and cost-effective validation to responsibly bridge the healthspan-lifespan gap for a future of equitable global wellbeing.
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U2 - 10.1038/s41536-021-00169-5
DO - 10.1038/s41536-021-00169-5
M3 - Review article
AN - SCOPUS:85115629158
SN - 2057-3995
VL - 6
JO - npj Regenerative Medicine
JF - npj Regenerative Medicine
IS - 1
M1 - 57
ER -