Irene Maeve Rea, Giuseppina Candore, Luca Cavallone, Fabiola Olivieri, Maurizio Cardelli, Claudio Franceschi, Giuseppina Colonna-Romano, Domenico Lio, Owen Anthony Ross, Calogero Caruso

Research output: Chapter in Book/Report/Conference proceedingChapter

10 Scopus citations


Life span is a multifactorial quantitative trait that is affected by genetic and environmental factors. It also contains a stochastic component resulting from the interaction between the individual’s chance of surviving and unpredictable events that occur throughout the life course. Advances in the treatment of fatal diseases and improvements in nutrition and living conditions led to a drastic reduction in death rate at young ages before 1950 and at old ages after 1950 in the developed world. As a result, mean life span has experienced a remarkable increase in developed countries.1 However, why some people live into their nineties or even become centenarians while others die earlier in life of infection, cancer, or inflammatory diseases such as atheroscelerosis, diabetes, or autoimmune disease remains largely unknown.

Original languageEnglish (US)
Title of host publicationCytokine Gene Polymorphisms in Multifactorial Conditions
PublisherCRC Press
Number of pages16
ISBN (Electronic)9781420005325
ISBN (Print)0849336198, 9780849336195
StatePublished - Jan 1 2006

ASJC Scopus subject areas

  • General Immunology and Microbiology
  • General Pharmacology, Toxicology and Pharmaceutics
  • General Biochemistry, Genetics and Molecular Biology
  • General Medicine


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