Long-term survival among patients operated upon for peptic ulcer disease

John M. Duggan, Alan R. Zinsmeister, Keith A. Kelly, L. Joseph Melton

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Background: Although surgery has been used widely for treating peptic ulcer disease, there is conflicting evidence with respect to subsequent life expectancy and the determinants of mortality. Our aim was to compare long- term survival in a large, population-based cohort of operated patients with that expected in the general population. Methods: We followed 471 Rochester, Minnesota residents who had surgery for peptic ulcer at the Mayo Clinic during 1956-85 for a total of 6174 person-years. Patients were followed through their complete (inpatient and outpatient) medical records in the community until death or last clinical contact and death certificates were obtained for all who succumbed. We compared observed survival and cause- specific death rates in this cohort with expected values and identified the determinants of short (30 day) and long-term mortality. Results and Conclusions: Survival was worse than expected, but excess deaths were confined to those with perforated ulcers (42 deaths observed; 18.8 expected). Independent predictors of death included age, male gender, emergency operation, gastric ulcer and cigarette smoking. Most deaths were due to heart disease and cancer, but only those due to digestive diseases (standardized mortality ratio (SMR) 3.8, 95% CI 2.4-5.7) and respiratory diseases (SMR 1.9, 95% CI 1.3-2.7) were increased compared to expected figures. Overall survival was reduced in this cohort but was normal among those whose ulcers were not perforated. However, the data suggest an adverse role for alcohol and smoking in these patients.

Original languageEnglish (US)
Pages (from-to)1074-1082
Number of pages9
JournalJournal of Gastroenterology and Hepatology (Australia)
Issue number11
StatePublished - Jan 1 1999


  • Epidemiology
  • Mortality
  • Peptic ulcer disease
  • Population-based study
  • Risk factors

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology


Dive into the research topics of 'Long-term survival among patients operated upon for peptic ulcer disease'. Together they form a unique fingerprint.

Cite this