Long-term Outcomes of Sequential Hematopoietic Stem Cell Transplantation and Kidney Transplantation: Single-center Experience

Carla Leal Moreira, M. Hasib Sidiqi, Francis K. Buadi, Mark R. Litzow, Morie A. Gertz, Angela Dispenzieri, Stephen J. Russell, Stephen M. Ansell, Mark D. Stegall, Mikel Prieto, Patrick G. Dean, Scott L. Nyberg, Mireille El Ters, William J. Hogan, Hatem Amer, Fernando G. Cosio, Nelson Leung

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Experience with sequential hematopoietic stem cell transplant (HSCT) and kidney transplant (KT) is limited. Methods. We conducted a retrospective observational study of adult patients who underwent both HSCT and KT at our center, with a median follow-up of 11 y. Results. In our 54 patients cohort (94% autologous HSCT), 36 (67%) patients received HSCT first followed by KT, while 18 (33%) received KT before HSCT. In both groups, AL amyloidosis represented 50% of hematologic diagnosis. Only 4 patients expired due to hematologic disease relapse (2 patients in each group) and only 3 allografts were lost due to hematologic disease recurrence (HSCT first n = 1 and KT first n = 2). Overall 1, 5, and 10 y death-censored graft survival rates were 94%, 94%, and 94%, respectively, for the HSCT first group and 89%, 89%, and 75%, respectively, for the KT first group. Overall 1, 5, and 10 y patients survival rates were 100%, 97% and 90%, respectively, for the HSCT first group and 100%, 76%, and 63%, respectively, for the KT first group. Conclusions. Our study supports safety of sequential KT and HSCT, with improved overall patient survival compared to recipients of HSCT remaining on dialysis and good long-term kidney allograft outcome.

Original languageEnglish (US)
Pages (from-to)1615-1624
Number of pages10
JournalTransplantation
Volume105
Issue number7
DOIs
StatePublished - Jul 1 2021

ASJC Scopus subject areas

  • Transplantation

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