Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research

M. R. Bishop; B. R. Logan; S. Gandham; B. J. Bolwell; J. Y. Cahn; H. M. Lazarus; M. R. Litzow; D. I. Marks; P. H. Wiernik; P. L. McCarthy; J. A. Russell; C. B. Miller; J. Sierra; G. Milone; A. Keating; F. R. Loberiza; S. Giralt; M. M. Horowitz; D. J. Weisdorf

doi:10.1038/sj.bmt.1705952

Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research

M. R. Bishop, B. R. Logan, S. Gandham, B. J. Bolwell, J. Y. Cahn, H. M. Lazarus, M. R. Litzow, D. I. Marks, P. H. Wiernik, P. L. McCarthy, J. A. Russell, C. B. Miller, J. Sierra, G. Milone, A. Keating, F. R. Loberiza, S. Giralt, M. M. Horowitz, D. J. Weisdorf

Hematology

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40 Scopus citations

Abstract

For adults with high-risk or recurrent ALL who lack a suitable sibling donor, the decision between autologous (Auto) and unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) is difficult due to variable risks of relapse and treatment-related mortality (TRM). We analysed data from two transplant registries to determine outcomes between Auto and URD HSCT for 260 adult ALL patients in first (CR1) or second (CR2) CR. All patients received a myeloablative conditioning regimen. The median follow-up was 77 (range 12-170) months. TRM at 1 year post transplant was significantly higher with URD HSCT; however, there were minimal differences in TRM according to disease status. Relapse was higher with Auto HSCT and was increased in patients transplanted in CR2. Five-year leukemia-free (37 vs 39%) and overall survival (OS) rates (38 vs 39%) were similar for Auto HSCT vs URD HSCT in CR1. There were trends favoring URD HSCT in CR2. The long-term follow-up in this analysis demonstrated that either Auto or URD HSCT could result in long-term leukaemia-free survival and OS for adult ALL patients. The optimal time (CR1 vs CR2) and technique to perform HSCT remains an important clinical question for adult ALL patients.

Original language	English (US)
Pages (from-to)	635-642
Number of pages	8
Journal	Bone Marrow Transplantation
Volume	41
Issue number	7
DOIs	https://doi.org/10.1038/sj.bmt.1705952
State	Published - Apr 2008

ASJC Scopus subject areas

Hematology
Transplantation

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Bishop, M. R., Logan, B. R., Gandham, S., Bolwell, B. J., Cahn, J. Y., Lazarus, H. M., Litzow, M. R., Marks, D. I., Wiernik, P. H., McCarthy, P. L., Russell, J. A., Miller, C. B., Sierra, J., Milone, G., Keating, A., Loberiza, F. R., Giralt, S., Horowitz, M. M., & Weisdorf, D. J. (2008). Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research. Bone Marrow Transplantation, 41(7), 635-642. https://doi.org/10.1038/sj.bmt.1705952

Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research. / Bishop, M. R.; Logan, B. R.; Gandham, S. et al.
In: Bone Marrow Transplantation, Vol. 41, No. 7, 04.2008, p. 635-642.

Research output: Contribution to journal › Article › peer-review

Bishop, MR, Logan, BR, Gandham, S, Bolwell, BJ, Cahn, JY, Lazarus, HM, Litzow, MR, Marks, DI, Wiernik, PH, McCarthy, PL, Russell, JA, Miller, CB, Sierra, J, Milone, G, Keating, A, Loberiza, FR, Giralt, S, Horowitz, MM & Weisdorf, DJ 2008, 'Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research', Bone Marrow Transplantation, vol. 41, no. 7, pp. 635-642. https://doi.org/10.1038/sj.bmt.1705952

Bishop MR, Logan BR, Gandham S, Bolwell BJ, Cahn JY, Lazarus HM et al. Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research. Bone Marrow Transplantation. 2008 Apr;41(7):635-642. doi: 10.1038/sj.bmt.1705952

Bishop, M. R. ; Logan, B. R. ; Gandham, S. et al. / Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation : A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research. In: Bone Marrow Transplantation. 2008 ; Vol. 41, No. 7. pp. 635-642.

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title = "Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research",

abstract = "For adults with high-risk or recurrent ALL who lack a suitable sibling donor, the decision between autologous (Auto) and unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) is difficult due to variable risks of relapse and treatment-related mortality (TRM). We analysed data from two transplant registries to determine outcomes between Auto and URD HSCT for 260 adult ALL patients in first (CR1) or second (CR2) CR. All patients received a myeloablative conditioning regimen. The median follow-up was 77 (range 12-170) months. TRM at 1 year post transplant was significantly higher with URD HSCT; however, there were minimal differences in TRM according to disease status. Relapse was higher with Auto HSCT and was increased in patients transplanted in CR2. Five-year leukemia-free (37 vs 39%) and overall survival (OS) rates (38 vs 39%) were similar for Auto HSCT vs URD HSCT in CR1. There were trends favoring URD HSCT in CR2. The long-term follow-up in this analysis demonstrated that either Auto or URD HSCT could result in long-term leukaemia-free survival and OS for adult ALL patients. The optimal time (CR1 vs CR2) and technique to perform HSCT remains an important clinical question for adult ALL patients.",

author = "Bishop, {M. R.} and Logan, {B. R.} and S. Gandham and Bolwell, {B. J.} and Cahn, {J. Y.} and Lazarus, {H. M.} and Litzow, {M. R.} and Marks, {D. I.} and Wiernik, {P. H.} and McCarthy, {P. L.} and Russell, {J. A.} and Miller, {C. B.} and J. Sierra and G. Milone and A. Keating and Loberiza, {F. R.} and S. Giralt and Horowitz, {M. M.} and Weisdorf, {D. J.}",

note = "Funding Information: This research has been supported by funding from the National Marrow Donor Program, the Health Resources and Services administration No. 240-97-0036 and the Office of Naval Research N00014-96-2-0016 and N00014-99-2-0006 to the National Marrow Donor Program.",

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T2 - A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research

AU - Bishop, M. R.

AU - Logan, B. R.

AU - Gandham, S.

AU - Bolwell, B. J.

AU - Cahn, J. Y.

AU - Lazarus, H. M.

AU - Litzow, M. R.

AU - Marks, D. I.

AU - Wiernik, P. H.

AU - McCarthy, P. L.

AU - Russell, J. A.

AU - Miller, C. B.

AU - Sierra, J.

AU - Milone, G.

AU - Keating, A.

AU - Loberiza, F. R.

AU - Giralt, S.

AU - Horowitz, M. M.

AU - Weisdorf, D. J.

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N2 - For adults with high-risk or recurrent ALL who lack a suitable sibling donor, the decision between autologous (Auto) and unrelated donor (URD) hematopoietic stem cell transplantation (HSCT) is difficult due to variable risks of relapse and treatment-related mortality (TRM). We analysed data from two transplant registries to determine outcomes between Auto and URD HSCT for 260 adult ALL patients in first (CR1) or second (CR2) CR. All patients received a myeloablative conditioning regimen. The median follow-up was 77 (range 12-170) months. TRM at 1 year post transplant was significantly higher with URD HSCT; however, there were minimal differences in TRM according to disease status. Relapse was higher with Auto HSCT and was increased in patients transplanted in CR2. Five-year leukemia-free (37 vs 39%) and overall survival (OS) rates (38 vs 39%) were similar for Auto HSCT vs URD HSCT in CR1. There were trends favoring URD HSCT in CR2. The long-term follow-up in this analysis demonstrated that either Auto or URD HSCT could result in long-term leukaemia-free survival and OS for adult ALL patients. The optimal time (CR1 vs CR2) and technique to perform HSCT remains an important clinical question for adult ALL patients.

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Long-term outcomes of adults with acute lymphoblastic leukemia after autologous or unrelated donor bone marrow transplantation: A comparative analysis by the National Marrow Donor Program and Center for International Blood and Marrow Transplant Research

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