Long-Term outcome of symptomatic infantile spasms established by video-electroencephalography (EEG) monitoring

Maria A. Montenegro, Karen Eck, Susan Jacob, Joshua Cappell, Claudia Chriboga, Ronald Emerson, Marc C. Patterson, Cigdem I. Akman

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


In this study, we examine the long-term clinical outcome of children with symptomatic infantile spasm. The children between 2 and 18 years of age diagnosed with symptomatic infantile spasms were reviewed. Sixty-eight children (age range, 2-13 years; mean, 4.5 years) met the inclusion criteria. Children who underwent epilepsy surgery were excluded. Age of onset for infantile spasms ranged from 1 to 24 months (mean, 7.1 months). Developmental delay was noted in all; there was seizure freedom in 14 children (20.5%). Infantile spasms were reported as the only seizure type in 10 (14.5%) children older than age 2 years. During the follow-up; symptomatic generalized epilepsy was diagnosed in 23 childern (34%) and focal epilepsy in 21 (31%). The long-term outcome of these children remains unchanged in the majority of the children with symptomatic infantile spasms. We could not establish any risk factor that might be related to favorable or adverse outcome.

Original languageEnglish (US)
Pages (from-to)1288-1292
Number of pages5
JournalJournal of child neurology
Issue number11
StatePublished - 2008


  • Epilepsy
  • Symptomatic infantile spasms
  • Video-electroencephalography (EEG) monitoring

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology


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