Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains.

Marjorie U. Yang; Anna N. Yaroslavsky; William A. Farinelli; Thomas J. Flotte; Francisca Rius-Diaz; Sandy S. Tsao; R. Rox Anderson

doi:10.1016/j.jaad.2004.10.876

Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains.

Marjorie U. Yang
, Anna N. Yaroslavsky
, William A. Farinelli
, Thomas J. Flotte
, Francisca Rius-Diaz
, Sandy S. Tsao
, R. Rox Anderson

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

129 Scopus citations

Abstract

OBJECTIVE: Laser treatment of port-wine stain (PWS) might be improved using a deeply penetrating wavelength. METHODS: PWSs in 17 patients were treated 3 times with a 595-nm pulsed dye laser (PDL) and a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Fluences of 1.0, 0.8, and 0.6 times the minimum purpura dose (MPD) were used for Nd:YAG laser. Posttreatment biopsy specimens were taken. Blind assessment and quantitative analysis of PWS clearing were performed from digital photographs. RESULTS: MPD for Nd:YAG laser varied widely, from 40 to 250 J/cm 2 . Purpura lasted longer after PDL. Treatment achieved similar 50% to 75% clearing with both PDL and Nd:YAG laser at 1 MPD. Nd:YAG caused greater perivascular and epidermal injury. Scarring occurred in the only patient treated with a Nd:YAG fluence greater than 1 MPD. Patients preferred Nd:YAG laser because of their faster recovery. CONCLUSION: Nd:YAG laser used at MPD is as effective as PDL for treating PWS. Nd:YAG laser fluences higher than MPD may cause scarring.

Original language	English (US)
Pages (from-to)	480-490
Number of pages	11
Journal	Journal of the American Academy of Dermatology
Volume	52
Issue number	3 Pt 1
DOIs	https://doi.org/10.1016/j.jaad.2004.10.876
State	Published - Mar 2005

ASJC Scopus subject areas

Dermatology

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10.1016/j.jaad.2004.10.876

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@article{391700a2fc284845bdff061b95cf2a5d,

title = "Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains.",

abstract = "OBJECTIVE: Laser treatment of port-wine stain (PWS) might be improved using a deeply penetrating wavelength. METHODS: PWSs in 17 patients were treated 3 times with a 595-nm pulsed dye laser (PDL) and a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Fluences of 1.0, 0.8, and 0.6 times the minimum purpura dose (MPD) were used for Nd:YAG laser. Posttreatment biopsy specimens were taken. Blind assessment and quantitative analysis of PWS clearing were performed from digital photographs. RESULTS: MPD for Nd:YAG laser varied widely, from 40 to 250 J/cm 2 . Purpura lasted longer after PDL. Treatment achieved similar 50\% to 75\% clearing with both PDL and Nd:YAG laser at 1 MPD. Nd:YAG caused greater perivascular and epidermal injury. Scarring occurred in the only patient treated with a Nd:YAG fluence greater than 1 MPD. Patients preferred Nd:YAG laser because of their faster recovery. CONCLUSION: Nd:YAG laser used at MPD is as effective as PDL for treating PWS. Nd:YAG laser fluences higher than MPD may cause scarring.",

author = "Yang, \{Marjorie U.\} and Yaroslavsky, \{Anna N.\} and Farinelli, \{William A.\} and Flotte, \{Thomas J.\} and Francisca Rius-Diaz and Tsao, \{Sandy S.\} and Anderson, \{R. Rox\}",

note = "Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine",

year = "2005",

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doi = "10.1016/j.jaad.2004.10.876",

language = "English (US)",

volume = "52",

pages = "480--490",

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T1 - Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains.

AU - Yang, Marjorie U.

AU - Yaroslavsky, Anna N.

AU - Farinelli, William A.

AU - Flotte, Thomas J.

AU - Rius-Diaz, Francisca

AU - Tsao, Sandy S.

AU - Anderson, R. Rox

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2005/3

Y1 - 2005/3

N2 - OBJECTIVE: Laser treatment of port-wine stain (PWS) might be improved using a deeply penetrating wavelength. METHODS: PWSs in 17 patients were treated 3 times with a 595-nm pulsed dye laser (PDL) and a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Fluences of 1.0, 0.8, and 0.6 times the minimum purpura dose (MPD) were used for Nd:YAG laser. Posttreatment biopsy specimens were taken. Blind assessment and quantitative analysis of PWS clearing were performed from digital photographs. RESULTS: MPD for Nd:YAG laser varied widely, from 40 to 250 J/cm 2 . Purpura lasted longer after PDL. Treatment achieved similar 50% to 75% clearing with both PDL and Nd:YAG laser at 1 MPD. Nd:YAG caused greater perivascular and epidermal injury. Scarring occurred in the only patient treated with a Nd:YAG fluence greater than 1 MPD. Patients preferred Nd:YAG laser because of their faster recovery. CONCLUSION: Nd:YAG laser used at MPD is as effective as PDL for treating PWS. Nd:YAG laser fluences higher than MPD may cause scarring.

AB - OBJECTIVE: Laser treatment of port-wine stain (PWS) might be improved using a deeply penetrating wavelength. METHODS: PWSs in 17 patients were treated 3 times with a 595-nm pulsed dye laser (PDL) and a 1064-nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser. Fluences of 1.0, 0.8, and 0.6 times the minimum purpura dose (MPD) were used for Nd:YAG laser. Posttreatment biopsy specimens were taken. Blind assessment and quantitative analysis of PWS clearing were performed from digital photographs. RESULTS: MPD for Nd:YAG laser varied widely, from 40 to 250 J/cm 2 . Purpura lasted longer after PDL. Treatment achieved similar 50% to 75% clearing with both PDL and Nd:YAG laser at 1 MPD. Nd:YAG caused greater perivascular and epidermal injury. Scarring occurred in the only patient treated with a Nd:YAG fluence greater than 1 MPD. Patients preferred Nd:YAG laser because of their faster recovery. CONCLUSION: Nd:YAG laser used at MPD is as effective as PDL for treating PWS. Nd:YAG laser fluences higher than MPD may cause scarring.

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IS - 3 Pt 1

ER -

Long-pulsed neodymium:yttrium-aluminum-garnet laser treatment for port-wine stains.

Abstract

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