Long-distance retrograde neurotrophic signaling

Charles L. Howe, William C. Mobley

Research output: Contribution to journalReview articlepeer-review

147 Scopus citations


The retrograde communication of neurotrophic signals from axon terminals to neuron cell bodies is crucial for neuron survival and plasticity. Several mechanisms have been proposed in the past, but recent evidence strongly supports the hypothesis that the retrograde propagation of self-regenerating signaling organelles, derived from the endocytosis of activated neurotrophin-bound receptor tyrosine kinases, is the primary mechanism responsible for this long-distance communication.

Original languageEnglish (US)
Pages (from-to)40-48
Number of pages9
JournalCurrent Opinion in Neurobiology
Issue number1
StatePublished - Feb 2005

ASJC Scopus subject areas

  • General Neuroscience


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