Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: Towards a multi-biomarker approach

M. B.I. Lobbes; M. E. Kooi; E. Lutgens; A. W. Ruiters; V. Lima Passos; S. H.J.G. Braat; M. Rousch; H. Ten Cate; J. M.A. Van Engelshoven; M. J.A.P. Daemen; S. Heeneman

doi:10.1155/2010/726207

Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: Towards a multi-biomarker approach

M. B.I. Lobbes
, M. E. Kooi
, E. Lutgens
, A. W. Ruiters
, V. Lima Passos
, S. H.J.G. Braat
, M. Rousch
, H. Ten Cate
, J. M.A. Van Engelshoven
, M. J.A.P. Daemen
, S. Heeneman

Cardiovascular Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.

Original language	English (US)
Article number	726207
Journal	International Journal of Vascular Medicine
Volume	2010
DOIs	https://doi.org/10.1155/2010/726207
State	Published - 2010

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1155/2010/726207

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Lobbes, M. B. I., Kooi, M. E., Lutgens, E., Ruiters, A. W., Lima Passos, V., Braat, S. H. J. G., Rousch, M., Ten Cate, H., Van Engelshoven, J. M. A., Daemen, M. J. A. P., & Heeneman, S. (2010). Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: Towards a multi-biomarker approach. International Journal of Vascular Medicine, 2010, Article 726207. https://doi.org/10.1155/2010/726207

Lobbes, MBI, Kooi, ME, Lutgens, E, Ruiters, AW, Lima Passos, V, Braat, SHJG, Rousch, M, Ten Cate, H, Van Engelshoven, JMA, Daemen, MJAP & Heeneman, S 2010, 'Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: Towards a multi-biomarker approach', International Journal of Vascular Medicine, vol. 2010, 726207. https://doi.org/10.1155/2010/726207

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title = "Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: Towards a multi-biomarker approach",

abstract = "We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83\% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.",

author = "Lobbes, \{M. B.I.\} and Kooi, \{M. E.\} and E. Lutgens and Ruiters, \{A. W.\} and \{Lima Passos\}, V. and Braat, \{S. H.J.G.\} and M. Rousch and \{Ten Cate\}, H. and \{Van Engelshoven\}, \{J. M.A.\} and Daemen, \{M. J.A.P.\} and S. Heeneman",

year = "2010",

doi = "10.1155/2010/726207",

language = "English (US)",

volume = "2010",

journal = "International Journal of Vascular Medicine",

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T2 - Towards a multi-biomarker approach

AU - Lobbes, M. B.I.

AU - Kooi, M. E.

AU - Lutgens, E.

AU - Ruiters, A. W.

AU - Lima Passos, V.

AU - Braat, S. H.J.G.

AU - Rousch, M.

AU - Ten Cate, H.

AU - Van Engelshoven, J. M.A.

AU - Daemen, M. J.A.P.

AU - Heeneman, S.

PY - 2010

Y1 - 2010

N2 - We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.

AB - We evaluated leukocyte counts and levels of CRP, fibrinogen, MPO, and PAPP-A in patients with stable and unstable angina pectoris, acute myocardial infarction, and healthy controls. All biomarkers were analyzed again after 6 months. Leukocyte counts and concentrations of fibrinogen, CRP, MPO, and PAPP-A were significantly increased in patients with acute myocardial infarction. Leukocyte counts and concentrations of MPO were significantly increased in patients with unstable angina pectoris compared with controls. After 6 months, leukocyte counts and MPO concentrations were still increased in patients with acute myocardial infarction when compared to controls. Discriminant analysis showed that leukocyte counts, MPO, and PAPP-A concentrations classified study group designation for acute coronary events correctly in 83% of the cases. In conclusion, combined assessment of leukocyte counts, MPO, and PAPP-A was able to correctly classify acute coronary events, suggesting that this could be a promising panel for a multibiomarker approach to assess cardiovascular risk.

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VL - 2010

JO - International Journal of Vascular Medicine

JF - International Journal of Vascular Medicine

M1 - 726207

ER -

Leukocyte counts, myeloperoxidase, and pregnancy-associated plasma protein a as biomarkers for cardiovascular disease: Towards a multi-biomarker approach

Abstract

ASJC Scopus subject areas

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