Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses

Makoto Kubo; Ryuichi Nagashima; Etsuro Ohta; Tatsunori Maekawa; Yumiko Isobe; Mitsue Kurihara; Koji Eshima; Kazuya Iwabuchi; Toshikuni Sasaoka; Sadahiro Azuma; Heather L. Melrose; Matthew J. Farrer; Fumiya Obata

doi:10.1016/j.jneuroim.2016.01.005

Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses

Makoto Kubo, Ryuichi Nagashima, Etsuro Ohta, Tatsunori Maekawa, Yumiko Isobe, Mitsue Kurihara, Koji Eshima, Kazuya Iwabuchi, Toshikuni Sasaoka, Sadahiro Azuma, Heather L. Melrose, Matthew J. Farrer, Fumiya Obata

Neuroscience

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRK2 mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRK2-knockout (LRRK2^-/-) mice. LRRK2^-/- mice had significantly higher counts of peritoneal B1 cells than wild-type mice. After BCR stimulation, phosphor-Erk1/2 of splenic B2 cells was enhanced to a higher degree in LRRK2^-/- mice. LRRK2^-/- mice had a significantly higher serum IgA level, and TNP-Ficoll immunization increased the titer of serum anti-TNP IgM antibody. LRRK2 may play important roles in B cells.

Original language	English (US)
Pages (from-to)	1-8
Number of pages	8
Journal	Journal of neuroimmunology
Volume	292
DOIs	https://doi.org/10.1016/j.jneuroim.2016.01.005
State	Published - Mar 15 2016

Keywords

B cell receptor signaling
B1 cell
B2 cell
IgA
Leucine-rich repeat kinase 2
TI antigen

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

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Kubo, M., Nagashima, R., Ohta, E., Maekawa, T., Isobe, Y., Kurihara, M., Eshima, K., Iwabuchi, K., Sasaoka, T., Azuma, S., Melrose, H. L., Farrer, M. J., & Obata, F. (2016). Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses. Journal of neuroimmunology, 292, 1-8. https://doi.org/10.1016/j.jneuroim.2016.01.005

Kubo, M, Nagashima, R, Ohta, E, Maekawa, T, Isobe, Y, Kurihara, M, Eshima, K, Iwabuchi, K, Sasaoka, T, Azuma, S, Melrose, HL, Farrer, MJ & Obata, F 2016, 'Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses', Journal of neuroimmunology, vol. 292, pp. 1-8. https://doi.org/10.1016/j.jneuroim.2016.01.005

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title = "Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses",

abstract = "LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRK2 mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRK2-knockout (LRRK2-/-) mice. LRRK2-/- mice had significantly higher counts of peritoneal B1 cells than wild-type mice. After BCR stimulation, phosphor-Erk1/2 of splenic B2 cells was enhanced to a higher degree in LRRK2-/- mice. LRRK2-/- mice had a significantly higher serum IgA level, and TNP-Ficoll immunization increased the titer of serum anti-TNP IgM antibody. LRRK2 may play important roles in B cells.",

keywords = "B cell receptor signaling, B1 cell, B2 cell, IgA, Leucine-rich repeat kinase 2, TI antigen",

author = "Makoto Kubo and Ryuichi Nagashima and Etsuro Ohta and Tatsunori Maekawa and Yumiko Isobe and Mitsue Kurihara and Koji Eshima and Kazuya Iwabuchi and Toshikuni Sasaoka and Sadahiro Azuma and Melrose, {Heather L.} and Farrer, {Matthew J.} and Fumiya Obata",

note = "Funding Information: This work was supported by All Kitasato Project Study Grant number 18-1 from Kitasato University School of Allied Health Sciences . Publisher Copyright: {\textcopyright} 2016 Elsevier B.V.",

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AU - Kubo, Makoto

AU - Nagashima, Ryuichi

AU - Ohta, Etsuro

AU - Maekawa, Tatsunori

AU - Isobe, Yumiko

AU - Kurihara, Mitsue

AU - Eshima, Koji

AU - Iwabuchi, Kazuya

AU - Sasaoka, Toshikuni

AU - Azuma, Sadahiro

AU - Melrose, Heather L.

AU - Farrer, Matthew J.

AU - Obata, Fumiya

PY - 2016/3/15

Y1 - 2016/3/15

N2 - LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRK2 mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRK2-knockout (LRRK2-/-) mice. LRRK2-/- mice had significantly higher counts of peritoneal B1 cells than wild-type mice. After BCR stimulation, phosphor-Erk1/2 of splenic B2 cells was enhanced to a higher degree in LRRK2-/- mice. LRRK2-/- mice had a significantly higher serum IgA level, and TNP-Ficoll immunization increased the titer of serum anti-TNP IgM antibody. LRRK2 may play important roles in B cells.

AB - LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRK2 mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRK2-knockout (LRRK2-/-) mice. LRRK2-/- mice had significantly higher counts of peritoneal B1 cells than wild-type mice. After BCR stimulation, phosphor-Erk1/2 of splenic B2 cells was enhanced to a higher degree in LRRK2-/- mice. LRRK2-/- mice had a significantly higher serum IgA level, and TNP-Ficoll immunization increased the titer of serum anti-TNP IgM antibody. LRRK2 may play important roles in B cells.

KW - B cell receptor signaling

KW - B1 cell

KW - B2 cell

KW - IgA

KW - Leucine-rich repeat kinase 2

KW - TI antigen

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ER -

Leucine-rich repeat kinase 2 is a regulator of B cell function, affecting homeostasis, BCR signaling, IgA production, and TI antigen responses

Abstract

Keywords

ASJC Scopus subject areas

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