Abstract
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with integrated transgenes. Safety issues, including insertional mutagenesis and replication-competent retroviruses, are discussed. Innate cellular defenses against retroviruses and their implications for human gene therapy with different lentiviral vectors are also addressed.
| Original language | English (US) |
|---|---|
| Title of host publication | Gene Therapy and Gene Delivery Systems |
| Pages | 169-191 |
| Number of pages | 23 |
| DOIs | |
| State | Published - Nov 8 2005 |
Publication series
| Name | Advances in Biochemical Engineering/Biotechnology |
|---|---|
| Volume | 99 |
| ISSN (Print) | 0724-6145 |
ASJC Scopus subject areas
- Biotechnology
- Bioengineering
- Applied Microbiology and Biotechnology
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