Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging

Janina Krell-Roesch, Nathanael T. Feder, Rosebud O. Roberts, Michelle M. Mielke, Teresa J. Christianson, David S. Knopman, Ronald C. Petersen, Yonas E. Geda

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


We conducted a prospective cohort study derived from the population-based Mayo Clinic Study of Aging. We investigated if leisure-time physical activity among individuals with mild cognitive impairment (MCI) was associated with a decreased risk of developing dementia. 280 persons aged≥70 years (median 81 years, 165 males) with MCI and available data from neurologic evaluation, neuropsychological testing, and questionnaire-based physical activity assessment, were followed for a median of 3 years to the outcomes of incident dementia or censoring variables. We conducted Cox proportional hazards regression analyses with age as a time scale and adjusted for sex, education, medical comorbidity, depression, and APOE ɛ4 status. Moderate intensity midlife physical activity among MCI participants was significantly associated with a decreased risk of incident dementia (HR = 0.64; 95% CI, 0.41-0.98). There was a non-significant trend for a decreased risk of dementia for light and vigorous intensity midlife physical activity, as well as light and moderate intensity late-life physical activity. In conclusion, we observed that physical activity may be associated with a reduced risk of dementia among individuals with MCI. Furthermore, intensity and timing of physical activity may be important factors when investigating this association.

Original languageEnglish (US)
Pages (from-to)149-155
Number of pages7
JournalJournal of Alzheimer's disease : JAD
Issue number1
StatePublished - 2018


  • APOE ɛ4
  • cohort study
  • incident dementia
  • mild cognitive impairment
  • physical activity

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Leisure-Time Physical Activity and the Risk of Incident Dementia: The Mayo Clinic Study of Aging'. Together they form a unique fingerprint.

Cite this