Leg free fatty acid kinetics during exercise in men and women

Bartolome Burguera, David Proctor, Niki Dietz, Zengkui Guo, Michael Joyner, Michael D. Jensen

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


We previously reported that epinephrine stimulates leg free fatty acid (FFA) release in men but not in women. The present studies were conducted to determine whether the same is true during exercise. Six men and six women bicycled for 90 min at 45% of peak O2 consumption, during which time systemic and leg FFA kinetics ([9,10-3H]palmitate) were measured. The catecholamine and hormonal responses to exercise were not different in men and women. The baseline systemic and leg palmitate release was 94 ± 15 vs. 114 ± 5 μmol/min and 16 ± 2 and 20 ± 3 μmol/min, respectively, in men and women [P = nonsignificant (NS)]. Systemic and leg palmitate release increased (both P < 0.001) to 251 ± 18 vs. 212 ± 16 μmol/min and 73 ± 19 vs. 80 ± 12 μmol/min in men and women, respectively, during the last 30 min of exercise (P = NS, men vs. women). We conclude that the systemic and leg adipose tissue lipolytic response to exercise is not different in nonobese men and women.

Original languageEnglish (US)
Pages (from-to)E113-E117
JournalAmerican Journal of Physiology - Endocrinology and Metabolism
Issue number1 41-1
StatePublished - Jan 2000


  • Body composition
  • Indirect calorimetry
  • Lipolysis

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Physiology
  • Physiology (medical)


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