TY - JOUR
T1 - Launching Effectiveness Research to Guide Practice in Neurosurgery
T2 - A National Institute Neurological Disorders and Stroke Workshop Report
AU - Workshop Participants
AU - Walicke, Patricia
AU - Abosch, Aviva
AU - Asher, Anthony
AU - Barker, Fred G.
AU - Ghogawala, Zoher
AU - Harbaugh, Robert
AU - Jehi, Lara
AU - Kestle, John
AU - Koroshetz, Walter
AU - Little, Roderick
AU - Rubin, Donald
AU - Valadka, Alex
AU - Wisniewski, Stephen
AU - Chiocca, E. Antonio
AU - Amin-Hanjani, Sepideh
AU - Barbaro, Nicholas
AU - Berger, Mitchell
AU - Berliner, Elise
AU - Blumenkopf, Bennett
AU - Brown, Robert D.
AU - Bydon, Mohammed
AU - Califf, Robert
AU - Chang, Eddie
AU - Chimowitz, Marc
AU - Connolly, Sander
AU - Dacey, Ralph
AU - Frangakis, Constantine
AU - Friedlander, Robert
AU - Fureman, Brandy
AU - Gutman, Roee
AU - Holloway, Robert
AU - Kim, Scott
AU - Kondziolka, Douglas
AU - Lonser, Russell
AU - Manley, Geoff
AU - Ojemann, Jeffrey
AU - Pena, Carlos
AU - Platt, Richard
AU - Sampson, John
AU - Schafer, Jyme
AU - Tosteson, Tor D.
AU - Vickrey, Barbara
AU - Warf, Benjamin
N1 - Funding Information:
This workshop was funded by the National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland. No authors or workshop participants have any personal, financial, or institutional interest in any of the drugs, materials, or devices described in this article.
Publisher Copyright:
Copyright © 2017 by the Congress of Neurological Surgeons.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice.Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."
AB - This workshop addressed challenges of clinical research in neurosurgery. Randomized controlled clinical trials (RCTs) have high internal validity, but often insufficiently generalize to real-world practice.Observational studies are inclusive but often lack sufficient rigor. The workshop considered possible solutions, such as (1) statistical methods for demonstrating causality using observational data; (2) characteristics required of a registry supporting effectiveness research; (3) trial designs combining advantages of observational studies and RCTs; and (4) equipoise, an identified challenge for RCTs. In the future, advances in information technology potentially could lead to creation of a massive database where clinical data from all neurosurgeons are integrated and analyzed, ending the separation of clinical research and practice and leading to a new "science of practice."
KW - Clinical trials
KW - Effectiveness research
KW - Equipoise
KW - Randomized controlled trial
KW - Registry
UR - http://www.scopus.com/inward/record.url?scp=85021644076&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85021644076&partnerID=8YFLogxK
U2 - 10.1093/neuros/nyw133
DO - 10.1093/neuros/nyw133
M3 - Article
C2 - 28362926
AN - SCOPUS:85021644076
SN - 0069-4827
VL - 80
SP - 505
EP - 514
JO - Clinical neurosurgery
JF - Clinical neurosurgery
IS - 4
ER -