TY - JOUR
T1 - Late Midlife Subclinical Infarct Burden and Risk of Dementia
T2 - The Atherosclerosis Risk in Communities Neurocognitive Study
AU - Sullivan, Kevin J.
AU - Griswold, Michael E.
AU - Ghelani, Kunali
AU - Rajesh, Aishwarya
AU - Shrestha, Srishti
AU - Gottesman, Rebecca F.
AU - Knopman, David
AU - Mosley, Thomas H.
AU - Windham, B. Gwen
N1 - Funding Information:
The Atherosclerosis Risk in Communities Study is carried out as a collaborative study supported by National Heart, Lung, and Blood Institute contracts (75N92022D00001, 75N92022D00002, 75N92022D00003, 75N92022D00004, 75N92022D00005). The ARIC Neurocognitive Study is supported by U01HL096812, U01HL096814, U01HL096899, U01HL096902, and U01HL096917 from the NIH (NHLBI, NINDS, NIA and NIDCD). Additional imaging dating was collected from R01 AG040282, and K24 AG052573 from the NIA. RFG was supported by the National Institute of Neurological Disorders and Stroke Intramural Research Program.
Publisher Copyright:
© 2023-IOS Press. All rights reserved.
PY - 2023
Y1 - 2023
N2 - At visit 3 (1993-1995) of the ARIC Study, 1.5T brain MRI was completed in 1,881 stroke-free participants (Mean age=62.9±4.9, 50% Black). Cox regression examined associations between infarct group [infarct-free (referent; n=1,611), smaller only (<3mm; n=50), larger only (≥3mm but <20mm; n=185), both (n=35)] and up to 25-year incident dementia (n=539). Participants with both infarcts were over 2.5 times more likely to develop dementia [HR=2.61; 95% CI=1.44, 4.72]. Smaller only (HR=1.22; 95% CI=0.70, 2.13) and larger only (HR=1.27; 95% CI=0.92, 1.74) groups showed associations with wide confidence intervals, unsupported statistically. A late midlife infarct profile including smaller and larger infarcts may represent particular vulnerability to dementia risk.
AB - At visit 3 (1993-1995) of the ARIC Study, 1.5T brain MRI was completed in 1,881 stroke-free participants (Mean age=62.9±4.9, 50% Black). Cox regression examined associations between infarct group [infarct-free (referent; n=1,611), smaller only (<3mm; n=50), larger only (≥3mm but <20mm; n=185), both (n=35)] and up to 25-year incident dementia (n=539). Participants with both infarcts were over 2.5 times more likely to develop dementia [HR=2.61; 95% CI=1.44, 4.72]. Smaller only (HR=1.22; 95% CI=0.70, 2.13) and larger only (HR=1.27; 95% CI=0.92, 1.74) groups showed associations with wide confidence intervals, unsupported statistically. A late midlife infarct profile including smaller and larger infarcts may represent particular vulnerability to dementia risk.
KW - Cerebrovascular disease
KW - cognition
KW - dementia
KW - epidemiology
KW - infarct
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U2 - 10.3233/JAD-220746
DO - 10.3233/JAD-220746
M3 - Article
C2 - 36463445
AN - SCOPUS:85147045940
SN - 1387-2877
VL - 91
SP - 543
EP - 549
JO - Journal of Alzheimer's Disease
JF - Journal of Alzheimer's Disease
IS - 2
ER -