Large common fragile site genes and cancer

David I. Smith, Sarah McAvoy, Yu Zhu, Damon S. Perez

Research output: Contribution to journalReview articlepeer-review

83 Scopus citations


The common fragile sites are large regions of genomic instability that are found in all individuals and are hot spots for chromosomal rearrangements and deletions. A number of the common fragile sites have been found to span genes that are encoded by very large genomic regions. Two of these genes, FHIT and WWOX, have already been demonstrated to function as tumor suppressors. In this review we will discuss the large common fragile site genes that have been identified to date, and the role that these genes appear to play both in cellular responses to stress and in the development of cancer.

Original languageEnglish (US)
Pages (from-to)31-41
Number of pages11
JournalSeminars in Cancer Biology
Issue number1
StatePublished - Feb 2007


  • Common fragile site
  • Large genes

ASJC Scopus subject areas

  • Cancer Research


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