Lack of FDG uptake in small cell carcinoma associated with ANNA-1 positive paraneoplastic autonomic neuropathy

Matthew S. Block; Robert Vassallo

doi:10.1097/JTO.0b013e31816e23ba

Lack of FDG uptake in small cell carcinoma associated with ANNA-1 positive paraneoplastic autonomic neuropathy

Matthew S. Block, Robert Vassallo

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A 76-year-old smoker presented with profound weight loss due to gastrointestinal dysmotility associated with high levels of the paraneoplastic antibody ANNA-1. Serial computed tomography scans showed regressing subcarinal adenopathy, and positron emission tomography imaging showed mild fluorodeoxy-d-glucose uptake in subcarinal nodes, suggestive of benign disease. Diagnosis of small cell carcinoma was established by biopsy of mediastinal nodes. This case highlights the importance of a thorough search for malignancy in patients with high levels of circulating autoantibodies and suggests that benign-appearing imaging studies be interpreted with caution in patients with paraneoplastic autoimmune syndromes.

Original language	English (US)
Pages (from-to)	542-544
Number of pages	3
Journal	Journal of Thoracic Oncology
Volume	3
Issue number	5
DOIs	https://doi.org/10.1097/JTO.0b013e31816e23ba
State	Published - May 2008

Keywords

ANNA-1
Autoimmune
PET
Paraneoplastic
Small cell cancer

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine

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10.1097/JTO.0b013e31816e23ba

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title = "Lack of FDG uptake in small cell carcinoma associated with ANNA-1 positive paraneoplastic autonomic neuropathy",

abstract = "A 76-year-old smoker presented with profound weight loss due to gastrointestinal dysmotility associated with high levels of the paraneoplastic antibody ANNA-1. Serial computed tomography scans showed regressing subcarinal adenopathy, and positron emission tomography imaging showed mild fluorodeoxy-d-glucose uptake in subcarinal nodes, suggestive of benign disease. Diagnosis of small cell carcinoma was established by biopsy of mediastinal nodes. This case highlights the importance of a thorough search for malignancy in patients with high levels of circulating autoantibodies and suggests that benign-appearing imaging studies be interpreted with caution in patients with paraneoplastic autoimmune syndromes.",

keywords = "ANNA-1, Autoimmune, PET, Paraneoplastic, Small cell cancer",

author = "Block, {Matthew S.} and Robert Vassallo",

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AU - Block, Matthew S.

AU - Vassallo, Robert

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AB - A 76-year-old smoker presented with profound weight loss due to gastrointestinal dysmotility associated with high levels of the paraneoplastic antibody ANNA-1. Serial computed tomography scans showed regressing subcarinal adenopathy, and positron emission tomography imaging showed mild fluorodeoxy-d-glucose uptake in subcarinal nodes, suggestive of benign disease. Diagnosis of small cell carcinoma was established by biopsy of mediastinal nodes. This case highlights the importance of a thorough search for malignancy in patients with high levels of circulating autoantibodies and suggests that benign-appearing imaging studies be interpreted with caution in patients with paraneoplastic autoimmune syndromes.

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KW - PET

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Lack of FDG uptake in small cell carcinoma associated with ANNA-1 positive paraneoplastic autonomic neuropathy

Abstract

Keywords

ASJC Scopus subject areas

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