Laboratory Work-Up of Chronic B-Cell Lymphoid Malignancies - A Value-Based Approach

Min Shi, Linda Dao, Dragan Jevremovic

Research output: Contribution to journalReview articlepeer-review


The aim of study was to summarize recent developments in laboratory work-up of lymphomas and discuss their clinical relevance. Diagnosis of lymphoma requires tissue biopsy with adequate work-up by pathologists. Recent developments in laboratory testing have raised the bar for establishing the diagnosis: more and more testing seems to be required, while the lines between research and clinical practice are being blurred. Academic medical practice is designed to push boundaries and test new hypotheses, which eventually result in improved patient care. Ability to (relatively) cheaply screen for multiple genomic abnormalities using new technologies is luring. Often, however, no change in patient management is pursued based on these results. It is therefore useful to review which testing is truly necessary from the patient's point of view. CONCLUSIONS: The laboratory work-up of lymphomas in a regular clinical practice requires relatively few tests. Many new tests have prognostic value, but do not necessarily contribute to the patient management.

Original languageEnglish (US)
Pages (from-to)45-56
Number of pages12
JournalActa medica academica
Issue number1
StatePublished - Apr 1 2019


  • Lymphoma
  • Pathology
  • Prognosis

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Laboratory Work-Up of Chronic B-Cell Lymphoid Malignancies - A Value-Based Approach'. Together they form a unique fingerprint.

Cite this