Laboratory findings in CD4(+) large granular lymphocytoses

H. Olteanu, N. J. Karandikar, C. Eshoa, S. H. Kroft

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Large granular lymphocytic (LGL) leukemia is an uncommon disorder of mature T or natural killer (NK) cells. Most T-LGL proliferations are CD3(+)/CD8(+), although rare CD4(+) clonal T-LGL expansions have been reported. We report the clinicopathologic features of eight patients with aberrant CD4(+), cytotoxic T-cell lymphocytoses. Median follow-up was 29 months (range 8-100), during which all were alive without requirement for therapy. Four of eight patients had an additional malignancy; none had a history of rheumatoid arthritis, lymphadenopathy or hepatosplenomegaly. Morphologic expansions of granulated lymphocytes were evident in 6/8. All had immunopheno- typically aberrant populations of CD4(+) T cells with uniform, moderate or bright CD56. Seven of eight expressed CD57, and four were CD8(partial dim +). Abnormal levels of expression of two or more T-cell antigens were seen in all cases. All tested cases were Tγ PCR positive. Our results support that CD4(+) T-LGL lymphocytosis is a clonal disorder with clinicopathologic characteristics distinct from the more common CD8(+) variant.

Original languageEnglish (US)
Pages (from-to)e9-e16
JournalInternational Journal of Laboratory Hematology
Issue number1 PART.1
StatePublished - Feb 2010


  • CD4
  • Flow cytometry
  • LGL
  • Large granular lymphocytosis
  • T-cell

ASJC Scopus subject areas

  • Hematology
  • Clinical Biochemistry
  • Biochemistry, medical


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