Isolated Left Ventricular Basal Ballooning Phenotype of Transient Cardiomyopathy in Young Women

Christina S. Reuss, Steven J. Lester, R. Todd Hurst, J. Wells Askew, Paul Nager, Joan Lusk, Gregory T. Altemose, A. Jamil Tajik

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63 Scopus citations


This report describes a variant of transient regional left ventricular dysfunction in which isolated basal left ventricular akinesia with normal mid-ventricular (papillary-level) wall motion and apical hypercontractility were noted in young women (mean age 31 years). This finding was demonstrated in 3 consecutive patients; the first patient was experiencing emotional life-altering events, and the second presented with an acute flare of multiple sclerosis. The third patient presented <24 hours after methamphetamine use. Coronary angiography demonstrated normal epicardial coronary arteries in all patients. Wall motion abnormalities resolved within 2 to 6 weeks. In conclusion, the entity described in this report is reminiscent of apical ballooning ("Tako-Tsubo"), mid-ventricular ballooning, and apical sparing syndromes; however, isolated basal left ventricular involvement has not been previously described and is a newer variant in the spectrum of transient cardiomyopathies. The pathophysiology of this entity has not been elucidated. A unifying feature between the transient cardiomyopathic syndromes most likely is in the concentration, distribution, and activity of cardiac adrenergic receptors.

Original languageEnglish (US)
Pages (from-to)1451-1453
Number of pages3
JournalAmerican Journal of Cardiology
Issue number10
StatePublished - May 15 2007

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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