Is Prediabetes a Risk Factor or is it a Disease?

Kalpana Muthusamy, Adrian Vella

Research output: Chapter in Book/Report/Conference proceedingChapter


Prediabetes can be characterized by one or both of impaired fasting glucose and impaired glucose tolerance. The increased prevalence of prediabetes and the high risk of progression to diabetes might present an opportunity to decrease the conversion rate to diabetes. The blood glucose concentrations that define prediabetes have been largely based on available evidence that assess progression to diabetes and the risk of micro- and macrovascular complications. Although the Oral Glucose Tolerance Test (OGTT) has historically been used to define the prediabetic state, fasting plasma glucose is more practical and perhaps more reproducible. Recent efforts have improved our understanding of the relative performance characteristics of the two tests. Risk factor clustering in patients with prediabetes mandates treatment of the associated risk factors to decrease the incidence and severity of subsequent macrovascular disease in affected patients.

Original languageEnglish (US)
Title of host publicationClinical Dilemmas in Diabetes
Number of pages8
ISBN (Print)9781405169288
StatePublished - Mar 31 2011


  • Diabetes
  • Impaired fasting glucose
  • Impaired glucose tolerance
  • Lifestyle modification
  • Macrovascular disease
  • Microvascular disease
  • OGTT
  • Pathogenesis
  • Prediabetes

ASJC Scopus subject areas

  • General Medicine


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