Is Continued Perioperative Antithrombotic Therapy Safe When Performing Direct Microlaryngoscopy?

Elias S. Saba, Michelle K. Higgins, Richard Heyes, David G. Lott

Research output: Contribution to journalArticlepeer-review


Objectives/Hypothesis: To evaluate whether antithrombotic status impacts the incidence of perioperative or postoperative bleeding in direct microlaryngoscopy (DML). Study Design: Retrospective chart review. Methods: Patients undergoing DML in a single surgeon's practice from September 2012 to September 2017 were studied. Included patients underwent DML with or without biopsy, balloon dilation, microsurgery, laser ablation, or vocal fold injection. Patients were stratified based on perioperative antithrombotic status and assessed for rates of peri- and postoperative bleeding and other complications. Results: Of the 581 patients meeting inclusion criteria, 179 patients (31%) had a history of baseline antithrombotic therapy. Of these patients, 124 had perioperative continuation of their therapy. Medicated patients were older (P <.01), predominately male (P <.01), and increasingly comorbid (P <.01). Perioperative complications unrelated to bleeding occurred in 22 patients (4%), minor perioperative bleeding occurred in four patients (0.7%), and minor postoperative bleeding occurred in 12 of the 479 patients with recorded follow-up (2.5%). There were no postoperative bleeds requiring intervention or readmission, and no recorded thrombotic events during the peri- and postoperative period. There was no difference in perioperative bleeding based on baseline antithrombotic status (P =.81). Patients on baseline antithrombotic therapy were more likely to have a postoperative bleed in comparison to patients without history of antithrombotic use (P <.01). However, there were no significant differences in postoperative bleeding between patients on baseline anticoagulation who continued or ceased their medication perioperatively (P =.45). Conclusions: Perioperative continuation of antithrombotic medications appears to be safe when performing routine DML. Level of Evidence: 4 Laryngoscope, 2020.

Original languageEnglish (US)
Pages (from-to)2853-2858
Number of pages6
Issue number12
StatePublished - Dec 2020


  • Direct microlaryngoscopy
  • anticoagulant therapy
  • anticoagulation
  • antiplatelet therapy
  • bleeding
  • complication

ASJC Scopus subject areas

  • Otorhinolaryngology


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