Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice

A. C. Zubair; S. A. Ali; R. C. Rees; J. R. Goepel; M. H. Goyns

doi:10.1016/0304-3835(96)04347-9

Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice

A. C. Zubair, S. A. Ali, R. C. Rees, J. R. Goepel, M. H. Goyns

Laboratory Medicine and Pathology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

We have assessed the effectiveness of the metalloproteinase inhibitor BB-94 (batimastat) in reducing the colonization potential of the human Burkitt lymphoma Namalwa cell line. In this study Namalwa cells were injected intraperitoneally into SCID mice and their spread to the spleen, liver and lung studied over a 3 week period. The human cells were detected in the mouse tissues by polymerase chain reaction (PCR) amplification of a human alu repeat sequence. Comparison of BB-94-treated animals with an untreated control group provided no evidence for a significant reduction in the colonization of mouse tissues by the human lymphoma cells in the presence of the drug. Tumour growth, after subcutaneous injection of the Namalwa cells into SCID mice, was similarly unaffected by BB-94. The significance of these results is discussed.

Original language	English (US)
Pages (from-to)	91-95
Number of pages	5
Journal	Cancer Letters
Volume	107
Issue number	1
DOIs	https://doi.org/10.1016/0304-3835(96)04347-9
State	Published - Oct 1 1996

Keywords

BB-94
Namalwa
Non-Hogkin's lymphoma
SCID mice

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1016/0304-3835(96)04347-9

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title = "Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice",

abstract = "We have assessed the effectiveness of the metalloproteinase inhibitor BB-94 (batimastat) in reducing the colonization potential of the human Burkitt lymphoma Namalwa cell line. In this study Namalwa cells were injected intraperitoneally into SCID mice and their spread to the spleen, liver and lung studied over a 3 week period. The human cells were detected in the mouse tissues by polymerase chain reaction (PCR) amplification of a human alu repeat sequence. Comparison of BB-94-treated animals with an untreated control group provided no evidence for a significant reduction in the colonization of mouse tissues by the human lymphoma cells in the presence of the drug. Tumour growth, after subcutaneous injection of the Namalwa cells into SCID mice, was similarly unaffected by BB-94. The significance of these results is discussed.",

keywords = "BB-94, Namalwa, Non-Hogkin's lymphoma, SCID mice",

author = "Zubair, {A. C.} and Ali, {S. A.} and Rees, {R. C.} and Goepel, {J. R.} and Goyns, {M. H.}",

note = "Funding Information: A.C.Z. acknowledges a postgraduates tudentship grant from the Kano State Government, Nigeria. This work was supported by the Yorkshire Cancer Research Campaign. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",

year = "1996",

month = oct,

day = "1",

doi = "10.1016/0304-3835(96)04347-9",

language = "English (US)",

volume = "107",

pages = "91--95",

journal = "Cancer Letters",

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AU - Zubair, A. C.

AU - Ali, S. A.

AU - Rees, R. C.

AU - Goepel, J. R.

AU - Goyns, M. H.

N1 - Funding Information: A.C.Z. acknowledges a postgraduates tudentship grant from the Kano State Government, Nigeria. This work was supported by the Yorkshire Cancer Research Campaign. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.

PY - 1996/10/1

Y1 - 1996/10/1

N2 - We have assessed the effectiveness of the metalloproteinase inhibitor BB-94 (batimastat) in reducing the colonization potential of the human Burkitt lymphoma Namalwa cell line. In this study Namalwa cells were injected intraperitoneally into SCID mice and their spread to the spleen, liver and lung studied over a 3 week period. The human cells were detected in the mouse tissues by polymerase chain reaction (PCR) amplification of a human alu repeat sequence. Comparison of BB-94-treated animals with an untreated control group provided no evidence for a significant reduction in the colonization of mouse tissues by the human lymphoma cells in the presence of the drug. Tumour growth, after subcutaneous injection of the Namalwa cells into SCID mice, was similarly unaffected by BB-94. The significance of these results is discussed.

AB - We have assessed the effectiveness of the metalloproteinase inhibitor BB-94 (batimastat) in reducing the colonization potential of the human Burkitt lymphoma Namalwa cell line. In this study Namalwa cells were injected intraperitoneally into SCID mice and their spread to the spleen, liver and lung studied over a 3 week period. The human cells were detected in the mouse tissues by polymerase chain reaction (PCR) amplification of a human alu repeat sequence. Comparison of BB-94-treated animals with an untreated control group provided no evidence for a significant reduction in the colonization of mouse tissues by the human lymphoma cells in the presence of the drug. Tumour growth, after subcutaneous injection of the Namalwa cells into SCID mice, was similarly unaffected by BB-94. The significance of these results is discussed.

KW - BB-94

KW - Namalwa

KW - Non-Hogkin's lymphoma

KW - SCID mice

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AN - SCOPUS:0030271644

SN - 0304-3835

VL - 107

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JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Investigation of the effect of BB-94 (batimastat) on the colonization potential of human lymphoma cells in SCID mice

Abstract

Keywords

ASJC Scopus subject areas

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