Invasive Nocardia Infections across Distinct Geographic Regions, United States

Simran Gupta; Leah M. Grant; Harry R. Powers; Kathryn E. Kimes; Ahmed Hamdi; Richard J. Butterfield; Juan Gea-Banacloche; Prakhar Vijayvargiya; D. Jane Hata; Diana M. Meza Villegas; Adrian C. Dumitrascu; Dana M. Harris; Razvan M. Chirila; Nan Zhang; Raymund R. Razonable; Shimon Kusne; Salvador Alvarez; Holenarasipur R. Vikram

doi:10.3201/eid2912.230673

Invasive Nocardia Infections across Distinct Geographic Regions, United States

Simran Gupta
, Leah M. Grant
, Harry R. Powers
, Kathryn E. Kimes
, Ahmed Hamdi
, Richard J. Butterfield
, Juan Gea-Banacloche
, Prakhar Vijayvargiya
, D. Jane Hata
, Diana M. Meza Villegas
, Adrian C. Dumitrascu
, Dana M. Harris
, Razvan M. Chirila
, Nan Zhang
, Raymund R. Razonable
, Shimon Kusne
, Salvador Alvarez
, Holenarasipur R. Vikram

Research output: Contribution to journal › Article › peer-review

Abstract

We reviewed invasive Nocardia infections in 3 noncontiguous geographic areas in the United States during 2011–2018. Among 268 patients with invasive nocardiosis, 48.2% were from Minnesota, 32.4% from Arizona, and 19.4% from Florida. Predominant species were N. nova complex in Minnesota (33.4%), N. cyriacigeorgica in Arizona (41.4%), and N. brasiliensis in Florida (17.3%). Transplant recipients accounted for 82/268 (30.6%) patients overall: 14 (10.9%) in Minnesota, 35 (40.2%) in Arizona, and 33 (63.5%) in Florida. Manifestations included isolated pulmonary nocardiosis among 73.2% of transplant and 84.4% of non–transplant patients and central nervous system involvement among 12.2% of transplant and 3.2% of non–transplant patients. N. farcinica (20.7%) and N. cyriacigeorgica (19.5%) were the most common isolates among transplant recipients and N. cyriacigeorgica (38.0%), N. nova complex (23.7%), and N. farcinica (16.1%) among non–transplant patients. Overall antimicrobial susceptibilities were similar across the 3 study sites.

Original language	English (US)
Pages (from-to)	2417-2425
Number of pages	9
Journal	Emerging infectious diseases
Volume	29
Issue number	12
DOIs	https://doi.org/10.3201/eid2912.230673
State	Published - 2023

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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Gupta, S., Grant, L. M., Powers, H. R., Kimes, K. E., Hamdi, A., Butterfield, R. J., Gea-Banacloche, J., Vijayvargiya, P., Hata, D. J., Meza Villegas, D. M., Dumitrascu, A. C., Harris, D. M., Chirila, R. M., Zhang, N., Razonable, R. R., Kusne, S., Alvarez, S., & Vikram, H. R. (2023). Invasive Nocardia Infections across Distinct Geographic Regions, United States. Emerging infectious diseases, 29(12), 2417-2425. https://doi.org/10.3201/eid2912.230673

Gupta, S, Grant, LM, Powers, HR, Kimes, KE, Hamdi, A, Butterfield, RJ, Gea-Banacloche, J, Vijayvargiya, P, Hata, DJ, Meza Villegas, DM, Dumitrascu, AC, Harris, DM, Chirila, RM, Zhang, N, Razonable, RR, Kusne, S, Alvarez, S & Vikram, HR 2023, 'Invasive Nocardia Infections across Distinct Geographic Regions, United States', Emerging infectious diseases, vol. 29, no. 12, pp. 2417-2425. https://doi.org/10.3201/eid2912.230673

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title = "Invasive Nocardia Infections across Distinct Geographic Regions, United States",

abstract = "We reviewed invasive Nocardia infections in 3 noncontiguous geographic areas in the United States during 2011–2018. Among 268 patients with invasive nocardiosis, 48.2\% were from Minnesota, 32.4\% from Arizona, and 19.4\% from Florida. Predominant species were N. nova complex in Minnesota (33.4\%), N. cyriacigeorgica in Arizona (41.4\%), and N. brasiliensis in Florida (17.3\%). Transplant recipients accounted for 82/268 (30.6\%) patients overall: 14 (10.9\%) in Minnesota, 35 (40.2\%) in Arizona, and 33 (63.5\%) in Florida. Manifestations included isolated pulmonary nocardiosis among 73.2\% of transplant and 84.4\% of non–transplant patients and central nervous system involvement among 12.2\% of transplant and 3.2\% of non–transplant patients. N. farcinica (20.7\%) and N. cyriacigeorgica (19.5\%) were the most common isolates among transplant recipients and N. cyriacigeorgica (38.0\%), N. nova complex (23.7\%), and N. farcinica (16.1\%) among non–transplant patients. Overall antimicrobial susceptibilities were similar across the 3 study sites.",

author = "Simran Gupta and Grant, \{Leah M.\} and Powers, \{Harry R.\} and Kimes, \{Kathryn E.\} and Ahmed Hamdi and Butterfield, \{Richard J.\} and Juan Gea-Banacloche and Prakhar Vijayvargiya and Hata, \{D. Jane\} and \{Meza Villegas\}, \{Diana M.\} and Dumitrascu, \{Adrian C.\} and Harris, \{Dana M.\} and Chirila, \{Razvan M.\} and Nan Zhang and Razonable, \{Raymund R.\} and Shimon Kusne and Salvador Alvarez and Vikram, \{Holenarasipur R.\}",

year = "2023",

doi = "10.3201/eid2912.230673",

language = "English (US)",

volume = "29",

pages = "2417--2425",

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AU - Gupta, Simran

AU - Grant, Leah M.

AU - Powers, Harry R.

AU - Kimes, Kathryn E.

AU - Hamdi, Ahmed

AU - Butterfield, Richard J.

AU - Gea-Banacloche, Juan

AU - Vijayvargiya, Prakhar

AU - Hata, D. Jane

AU - Meza Villegas, Diana M.

AU - Dumitrascu, Adrian C.

AU - Harris, Dana M.

AU - Chirila, Razvan M.

AU - Zhang, Nan

AU - Razonable, Raymund R.

AU - Kusne, Shimon

AU - Alvarez, Salvador

AU - Vikram, Holenarasipur R.

PY - 2023

Y1 - 2023

N2 - We reviewed invasive Nocardia infections in 3 noncontiguous geographic areas in the United States during 2011–2018. Among 268 patients with invasive nocardiosis, 48.2% were from Minnesota, 32.4% from Arizona, and 19.4% from Florida. Predominant species were N. nova complex in Minnesota (33.4%), N. cyriacigeorgica in Arizona (41.4%), and N. brasiliensis in Florida (17.3%). Transplant recipients accounted for 82/268 (30.6%) patients overall: 14 (10.9%) in Minnesota, 35 (40.2%) in Arizona, and 33 (63.5%) in Florida. Manifestations included isolated pulmonary nocardiosis among 73.2% of transplant and 84.4% of non–transplant patients and central nervous system involvement among 12.2% of transplant and 3.2% of non–transplant patients. N. farcinica (20.7%) and N. cyriacigeorgica (19.5%) were the most common isolates among transplant recipients and N. cyriacigeorgica (38.0%), N. nova complex (23.7%), and N. farcinica (16.1%) among non–transplant patients. Overall antimicrobial susceptibilities were similar across the 3 study sites.

AB - We reviewed invasive Nocardia infections in 3 noncontiguous geographic areas in the United States during 2011–2018. Among 268 patients with invasive nocardiosis, 48.2% were from Minnesota, 32.4% from Arizona, and 19.4% from Florida. Predominant species were N. nova complex in Minnesota (33.4%), N. cyriacigeorgica in Arizona (41.4%), and N. brasiliensis in Florida (17.3%). Transplant recipients accounted for 82/268 (30.6%) patients overall: 14 (10.9%) in Minnesota, 35 (40.2%) in Arizona, and 33 (63.5%) in Florida. Manifestations included isolated pulmonary nocardiosis among 73.2% of transplant and 84.4% of non–transplant patients and central nervous system involvement among 12.2% of transplant and 3.2% of non–transplant patients. N. farcinica (20.7%) and N. cyriacigeorgica (19.5%) were the most common isolates among transplant recipients and N. cyriacigeorgica (38.0%), N. nova complex (23.7%), and N. farcinica (16.1%) among non–transplant patients. Overall antimicrobial susceptibilities were similar across the 3 study sites.

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JO - Emerging infectious diseases

JF - Emerging infectious diseases

IS - 12

ER -

Invasive Nocardia Infections across Distinct Geographic Regions, United States

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ASJC Scopus subject areas

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