Intraventricular infusion of HBGF-2 promotes cerebral angiogenesis in Wistar rat

Michael Puumala, Robert E. Anderson, Fredric B. Meyer

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


The angiogenic effects of chronic intraventricular infusion of basic fibroblastic growth factor (HBGF-2) were assessed in the Wistar rat cerebral cortex. HBGF-2 increased both capillary density and area of perfused vasculature without altering capillary diameters in periventricular cortex adjacent to the site of infusion. Although it has been demonstrated that growth factors can cause brain endothelial proliferation in vitro, this is the first report of in vivo cerebral angiogenesis.

Original languageEnglish (US)
Pages (from-to)283-286
Number of pages4
JournalBrain Research
Issue number1-2
StatePublished - Nov 26 1990


  • Angiogenesis
  • Capillary
  • Cerebral
  • Growth factor
  • Ischemia

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology


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