Intra-articular bone marrow concentrate injection protocol: Short-term efficacy in osteoarthritis

Steven Sampson, Jay Smith, Hunter Vincent, Danielle Aufiero, Mona Zall, Angie Botto-Van-Bemden

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Aim: Evaluate intra-articular injection of bone marrow concentrate (BMC), followed by platelet-rich plasma (PRP) injection at 8 weeks follow-up in moderate/severe osteoarthritis. Design: Single center, retrospective Case Series (n = 125). Methods: Bone marrow was aspirated/concentrated using a standardized technique. Patients received a single intra-articular injection of BMC, with follow-up injection of PRP at 8 weeks. Results: Median absolute pain reduction in all joints was five points (71.4%) on visual analog scale. Median patient satisfaction was 9.0/10, while 91.7% indicated that they would repeat the procedure and 94% said that they would recommend the procedure to a friend. Conclusion: Intra-articular injection of BMC, followed by a PRP injection, can provide short-term benefits in moderate-to-severe osteoarthritis.

Original languageEnglish (US)
Pages (from-to)511-520
Number of pages10
JournalRegenerative Medicine
Issue number6
StatePublished - Sep 2016


  • bone marrow concentrate
  • orthobiologics
  • osteoarthritis
  • platelet-rich plasma

ASJC Scopus subject areas

  • Biomedical Engineering
  • Embryology


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