Intestinal Failure: New Definition and Clinical Implications

Matthew Kappus, Sarah Diamond, Ryan T. Hurt, Robert Martindale

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations


Intestinal failure (IF) is a state in which the nutritional demands of the body are not met by the gastrointestinal absorptive surface. It is a long-recognized complication associated with short bowel syndrome, which results in malabsorption after significant resection of the intestine for many reasons or functional dysmotility. Etiologies have included Crohn’s disease, vascular complications, and the effects of radiation enteritis, as well as the effects of intestinal obstruction, dysmotility, or congenital defects. While IF has been long-recognized, it has historically not been uniformly defined, which has made both recognition and management challenging. This review examines the previous definitions of IF as well as the newer definition and classification of IF and how it is essential to IF clinical guidelines.

Original languageEnglish (US)
Article number48
JournalCurrent gastroenterology reports
Issue number9
StatePublished - Sep 1 2016


  • Acute intestinal failure
  • Chronic intestinal failure
  • Home parenteral nutrition
  • Intestinal failure
  • Short bowel syndrome
  • Short gut syndrome

ASJC Scopus subject areas

  • Gastroenterology


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