Intestinal cell cycle regulation.

T. C. Ko, W. A. Bresnahan, E. A. Thompson

Research output: Contribution to journalReview articlepeer-review

32 Scopus citations


The intestinal epithelium is maintained by a balance between proliferation, differentiation and death that occurs as cells migrate up the crypt-villus axis. Cell cycle regulators such as cyclins, cyclin-dependent kinases (Cdks) and Cdk inhibitory proteins are expressed in a distinct pattern along the crypt-villus structure, suggesting their role in controlling intestinal cells. This is supported by observations that these cell cycle proteins are regulated by growth factors, nutrients and cell-cell contact in cultured intestinal epithelial cells. One of the key regulators of intestinal cell proliferation and differentiation is transforming growth factor-beta, which is expressed in the gut epithelium.

Original languageEnglish (US)
Pages (from-to)43-52
Number of pages10
JournalProgress in cell cycle research
StatePublished - 1997

ASJC Scopus subject areas

  • General Medicine


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