Interstitial lung fluid balance in healthy lowlanders exposed to high-altitude

Bryan J. Taylor, Glenn M. Stewart, Jan W. Marck, Douglas T. Summerfield, Amine N. Issa, Bruce D. Johnson

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


We aimed to assess lung fluid balance before and after gradual ascent to 5150 m. Lung diffusion capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO) and ultrasound lung comets (ULCs) were assessed in 12 healthy lowlanders at sea-level, and on Day 1, Day 5 and Day 9 after arrival at Mount Everest Base Camp (EBC). EBC was reached following an 8-day hike at progressively increasing altitudes starting at 2860 m. DLCO was unchanged from sea-level to Day 1 at EBC, but increased on Day 5 (11 ± 10%) and Day 9 (10 ± 9%) vs. sea-level (P ≤ 0.047). DmCO increased from sea-level to Day 1 (9 ± 6%), Day 5 (12 ± 8%), and Day 9 (17 ± 11%) (all P ≤ 0.001) at EBC. There was no change in ULCs from sea-level to Day 1, Day 5 and Day 9 at EBC. These data provide evidence that interstitial lung fluid remains stable or may even decrease relative to at sea-level following 8 days of gradual exposure to high-altitude in healthy humans.

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalRespiratory Physiology and Neurobiology
StatePublished - Sep 2017


  • High-altitude pulmonary oedema
  • Hypoxia
  • Lung diffusing capacity
  • Ultrasound lung comets

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology
  • Pulmonary and Respiratory Medicine


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