@article{14589cdff66b4aa29f1534d3a2a62ca9,
title = "Interpretation of volumetric laser endomicroscopy in Barrett's esophagus using image enhancement software",
abstract = "Image interpretation of Barrett's esophagus (BE) with volumetric laser endomicroscopy (VLE) can be enhanced by image processing software that highlights established features using a color-graded scale (intelligent real-time image segmentation, IRIS). This study aims to provide a description of IRIS features of various gastroesophageal tissue types using histologic correlation. A database of 80 VLE laser-marked targets with histologic correlation was reviewed for various tissue types. IRIS was applied off-line to the VLE scans, laser-marked targets were identified, and feature review was performed. Squamous epithelium targets (N = 7) showed IRIS layered architecture with lack of surface hyper-reflectivity and epithelial glands. Gastric cardia targets (N = 10) showed absent layering (100%) and surface hyper-reflectivity with epithelial glands (40%). Nondysplastic BE targets (N = 39) showed surface hyper-reflectivity (64%), epithelial glands (51%), and lack of layering (74%). Targets of BE with early neoplasia (N = 24), showed surface hyper-reflectivity (96%), epithelial glands (67%), and lack of layering (96%). IRIS features that characterize each tissue type appear to mirror the nonenhanced VLE counterparts that define them.",
keywords = "Barrett's esophagus, Intelligent real-time image segmentation, Volumetric laser endomicroscopy",
author = "Kamboj, {A. K.} and P. Hoversten and Kahn, {A. K.} and Trindade, {A. J.} and Iyer, {P. G.} and Wang, {K. K.} and Leggett, {C. L.}",
note = "Funding Information: Address correspondence to: Cadman L. Leggett, MD, Division of Gastroenterology and Hepatology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Email: leggett.cadman@mayo.edu Specific author contributions: Study concept and design and acquisition of data: Amrit K. Kamboj, Patrick Hoversten, Allon Kahn, Cadman L. Leggett; Analysis and interpretation of data and drafting of the manuscript: Amrit K. Kamboj, Patrick Hoversten, Allon Kahn, Arvind J. Trindade, Prasad G. Iyer, Kenneth K. Wang, Cadman L. Leggett; Critical revision of the manuscript for important intellectual content: Amrit K. Kamboj, Allon Kahn, Arvind J. Trindade, Prasad G. Iyer, Kenneth K. Wang, Cadman L. Leggett; Statistical analysis and study supervision: Cadman L. Leggett. Financial support: This study was made possible through the support of the Charles F. & Marcia L. Forcey DCA in Esophageal Cancer Research Honoring Claude Deschamps, M.D., T.S. and by UO1CA182940. Conflicts of interest: Cadman L. Leggett, Prasad G. Iyer, and Allon Kahn disclose indirect research support from NinePoint Medical. Kenneth K. Wang is a consultant for NinePoint Medical. The other authors have no conflicts of interest to report. {\textcopyright}C The Author(s) 2019. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com Publisher Copyright: {\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of International Society for Diseases of the Esophagus. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2019",
month = nov,
day = "1",
doi = "10.1093/dote/doz037",
language = "English (US)",
volume = "32",
journal = "Diseases of the Esophagus",
issn = "1120-8694",
publisher = "Wiley-Blackwell",
number = "11",
}