International study on low-grade primary central nervous system lymphoma

Kristoph Jahnke, Agnieszka Korfei, Brian Patrick O'Neill, Jean Yves Blay, Lauren E. Abrey, Peter Martus, Philip M.P. Poortmans, Tamara N. Shenkier, Tracy T. Batchelor, Edward A. Neuwelt, Jeffrey J. Raizer, David Schiff, Hendrik Pels, Ulrich Herrlinger, Harald Stein, Eckhard Thiel

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Objective: The aim of this study was to characterize the clinical presentation, course, and outcome of low-grade primary central nervous system lymphoma. Methods: Cases were assessed in a retrospective series collected from 18 cancer centers in 5 countries. Results: Forty patients (18 men, 22 women; median age, 60 years [range, 19-78]) were identified. Involvement of a cerebral hemisphere or deeper brain structures was seen in 37 patients, only leptomeningeal involvement in 2 patients, and spinal cord disease in 1 patient. Chemotherapy/radiotherapy was conducted in 15 patients, radiotherapy alone in 12, chemotherapy alone in 10, and tumor resection alone in 2, whereas 1 patient received no treatment. The median progression-free, disease-specific, and overall survival were 61.5 (range, 0-204), 130 (range, 1-204), and 79 (range, 1-204) months, respectively. Only age 60 years or older was associated with shorter progression-free (p = 0.009), disease-specific (p = 0.015), and overall survival (p = 0.001) in multivariate analysis. Interpretation: Low-grade primary central nervous system lymphoma differs from the high-grade subtype in its pathological, clinical, and radiological features. It has a better long-term outcome than primary central nervous system lymphoma in general with age 60 years or older adversely affecting survival.

Original languageEnglish (US)
Pages (from-to)755-762
Number of pages8
JournalAnnals of neurology
Issue number5
StatePublished - May 2006

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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