Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats

Mi Hyeon Jang; Sae Bin Jung; Myoung Hwa Lee; Hong Kim; Sam Jun Lee; Young Je Sim; Hee Hyuk Lee; Eun Kyung Kim; Chang Ju Kim; Hye Sook Shin; Jeongseon Kim; Ee Hwa Kim

doi:10.1016/j.neulet.2004.12.009

Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats

Mi Hyeon Jang, Sae Bin Jung, Myoung Hwa Lee, Hong Kim, Sam Jun Lee, Young Je Sim, Hee Hyuk Lee, Eun Kyung Kim, Chang Ju Kim, Hye Sook Shin, Jeongseon Kim, Ee Hwa Kim

Neurosurgery

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.

Original language	English (US)
Pages (from-to)	44-48
Number of pages	5
Journal	Neuroscience Letters
Volume	378
Issue number	1
DOIs	https://doi.org/10.1016/j.neulet.2004.12.009
State	Published - Apr 11 2005

Keywords

Hippocampus
Immunohistochemistry
Maternal alcohol
RT-PCR
c-Fos

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/j.neulet.2004.12.009

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title = "Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats",

abstract = "Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.",

keywords = "Hippocampus, Immunohistochemistry, Maternal alcohol, RT-PCR, c-Fos",

author = "Jang, {Mi Hyeon} and Jung, {Sae Bin} and Lee, {Myoung Hwa} and Hong Kim and Lee, {Sam Jun} and Sim, {Young Je} and Lee, {Hee Hyuk} and Kim, {Eun Kyung} and Kim, {Chang Ju} and Shin, {Hye Sook} and Jeongseon Kim and Kim, {Ee Hwa}",

note = "Funding Information: This work was supported by a grant from the Health Fellowship Foundation of the Republic of Korea.",

year = "2005",

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day = "11",

doi = "10.1016/j.neulet.2004.12.009",

language = "English (US)",

volume = "378",

pages = "44--48",

journal = "Neuroscience Letters",

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AU - Jang, Mi Hyeon

AU - Jung, Sae Bin

AU - Lee, Myoung Hwa

AU - Kim, Hong

AU - Lee, Sam Jun

AU - Sim, Young Je

AU - Lee, Hee Hyuk

AU - Kim, Eun Kyung

AU - Kim, Chang Ju

AU - Shin, Hye Sook

AU - Kim, Jeongseon

AU - Kim, Ee Hwa

N1 - Funding Information: This work was supported by a grant from the Health Fellowship Foundation of the Republic of Korea.

PY - 2005/4/11

Y1 - 2005/4/11

N2 - Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.

AB - Maternal alcohol consumption during pregnancy is known to have a detrimental effect on the development of the fetus and its central nervous system (CNS) in particular. In the present study, the dose-dependence of the effect of maternal alcohol on hippocampal c-Fos expression, which is a marker of hippocampal neuronal activity and which is induced by a variety of stimuli, was examined in infant rats. In the present study, it was shown that expression of c-Fos in the hippocampus is decreased following treatment with alcohol in a dose-dependent fashion. Based on the results of the present study and the findings of other studies, it can be suggested that suppression of c-Fos expression in the hippocampus of infant rats with maternal alcohol administration mediates the associated developmental retardation and/or anomalies.

KW - Hippocampus

KW - Immunohistochemistry

KW - Maternal alcohol

KW - RT-PCR

KW - c-Fos

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SN - 0304-3940

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JO - Neuroscience Letters

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Influence of maternal alcohol administration on c-Fos expression in the hippocampus of infant rats

Abstract

Keywords

ASJC Scopus subject areas

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