TY - JOUR
T1 - Increased right ventricular afterload induces postsystolic thickening of the ventricular septum in nonischemic hearts
AU - Urheim, Stig
AU - Abraham, Theodore P.
AU - Korinek, Josef
AU - Wang, Jian Wen
AU - Belohlavek, Marek
N1 - Funding Information:
Supported in part by National Institutes of Health Grants HL68555 and HL70363 and by an American Heart Association Established Investigator Grant.
PY - 2005/8
Y1 - 2005/8
N2 - Background: We aimed to assess whether myocardial postsystolic thickening (PST) can be induced by an acute increase in right ventricular (RV) afterload and, thus, demonstrate that PST may have a nonischemic cause. Methods: In 8 anesthetized open-chest pigs, radial strains of the interventricular septum (IVS) and left ventricular inferolateral wall were obtained by Doppler tissue echocardiography before and during constriction of the pulmonary artery. Results: After each constriction, RV peak systolic pressure increased from 30 ± 5 to 57 ± 8 mm Hg (P < .001). Peak systolic radial strain of the IVS decreased from 20.8% ± 5.3% to 9.5% ± 4.1% (P = .003), and PST of the IVS increased from 0.3% ± 0.5% to 6.1% ± 4.8% (P = .01). The onset of PST started 41 ± 20 milliseconds after peak negative dP/dt of RV pressure. The inferolateral wall did not show PST. Conclusion: An acute increase in RV pressure causes a significant reduction in peak systolic strain of the IVS associated with the nonischemic appearance of PST.
AB - Background: We aimed to assess whether myocardial postsystolic thickening (PST) can be induced by an acute increase in right ventricular (RV) afterload and, thus, demonstrate that PST may have a nonischemic cause. Methods: In 8 anesthetized open-chest pigs, radial strains of the interventricular septum (IVS) and left ventricular inferolateral wall were obtained by Doppler tissue echocardiography before and during constriction of the pulmonary artery. Results: After each constriction, RV peak systolic pressure increased from 30 ± 5 to 57 ± 8 mm Hg (P < .001). Peak systolic radial strain of the IVS decreased from 20.8% ± 5.3% to 9.5% ± 4.1% (P = .003), and PST of the IVS increased from 0.3% ± 0.5% to 6.1% ± 4.8% (P = .01). The onset of PST started 41 ± 20 milliseconds after peak negative dP/dt of RV pressure. The inferolateral wall did not show PST. Conclusion: An acute increase in RV pressure causes a significant reduction in peak systolic strain of the IVS associated with the nonischemic appearance of PST.
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U2 - 10.1016/j.echo.2004.12.014
DO - 10.1016/j.echo.2004.12.014
M3 - Article
C2 - 16084336
AN - SCOPUS:23444433198
SN - 0894-7317
VL - 18
SP - 839
EP - 843
JO - Journal of the American Society of Echocardiography
JF - Journal of the American Society of Echocardiography
IS - 8
ER -